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Cytogenetic investigations of mutagenic action of caffeine in premeiotic spermiogenesis in mice

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Abstract

14 male mice (C3H) were treated with maximal tolerated doses of 1-3-7-trimethylxanthine (caffeine). Animals were sacrificed and preparations of testicular tissue examined in intervals after treatment. The meiotic chromosomes at Metaphase I (Diakinesis) were studied by phase contrast microscopy for breaks, translocations and univalent chromosomes. No unusual chromosome changes could be found.

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  1. Institut für Anthropologie und Humangenetik der Universität Heidelberg, Heidelberg, Germany

    Ilse-Dore Adler

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  1. Ilse-Dore Adler
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Adler, ID. Cytogenetic investigations of mutagenic action of caffeine in premeiotic spermiogenesis in mice. Hum Genet 3, 82–83 (1966). https://doi.org/10.1007/BF00273022

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  • DOI: https://doi.org/10.1007/BF00273022

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