Summary
Apl, a gene involved in the processing of lysosomal acid phosphatase in mouse liver, has been mapped on Chromosome 17. The gene order and map distances in per cent recombination of the loci studied are T (20.6±3.4) Pgk-2 (7.4±2.2) Apl. Thus, Apl is at least 7 cM distal to H-2 on this chromosome. In addition, strain-specific allelic variants for Apl have been demonstrated on cellulose acetate gels, a quick and inexpensive method of electrophoresis.
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Communicated by K. Illmensee
This work was supported by Contract NO1-ES42159 with the National Institute of Environmental Health Sciences, Grant 1–476 from the National Foundation, March of Dimes, and Grant GM 20919 from the National Institute of General Medical Sciences. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care
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Womack, J.E., Eicher, E.M. Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse chromosome 17. Molec. Gen. Genet. 155, 315–317 (1977). https://doi.org/10.1007/BF00272811
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DOI: https://doi.org/10.1007/BF00272811