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Permeability of the rat bladder to cisplatinum under different conditions: Comparison with mitomycin C and adriamycin

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Summary

In 50 female Sprague-Dawley rats the absorption of Cisplatinum through the bladder wall was studied. Under different conditions, including cystitis and electrocoagulation of the bladder mucosa, the absorption was low and the measureable serum concentrations did not exceed 2.64 μg/ml. The influence of Tween 80 — a non-ionic surfactant — on the absorption is investigated. The results are compared with those found for Adriamycin and Mitomycin C under identical conditions.

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Authors and Affiliations

  1. Department of Urology, University of Mainz Medical School, Mainz, Federal Republic of Germany

    U. Engelmann, G. Oelsner & R. A. Bürger

  2. Department of Clinical Chemistry, Medical University Hospital, Göttingen, Federal Republic of Germany

    H. Wagner

Authors
  1. U. Engelmann
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  2. G. Oelsner
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  3. R. A. Bürger
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  4. H. Wagner
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Parts of this study are included in a thesis

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Engelmann, U., Oelsner, G., Bürger, R.A. et al. Permeability of the rat bladder to cisplatinum under different conditions: Comparison with mitomycin C and adriamycin. Urol. Res. 11, 39–42 (1983). https://doi.org/10.1007/BF00272708

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  • DOI: https://doi.org/10.1007/BF00272708

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