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Gd(+)Cuiabá, a new rare glucose-6-phosphate dehydrogenase variant presenting normal activity

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Summary

A 33-year-old Brazilian male of Portuguese extraction was found to have a new glucose-6-phosphate dehydrogenase variant, herein named Gd(+)Cuiabá. The enzyme variant is characterized by normal activity, normal electrophoretic mobility, high Km, for glucose-6-phosphate, high Ki for NADPH, decreased thermal stability, normal utilization of substrate analogues and normal pH curve.

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Authors and Affiliations

  1. Laboratório de Pesquisas Hematológicas, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, 01246, São Paulo, Brazil

    Orlando C. O. de Barretto & Kimiyo Nonoyama

Authors
  1. Orlando C. O. de Barretto
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  2. Kimiyo Nonoyama
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de Barretto, O.C.O., Nonoyama, K. Gd(+)Cuiabá, a new rare glucose-6-phosphate dehydrogenase variant presenting normal activity. Hum Genet 77, 201–202 (1987). https://doi.org/10.1007/BF00272394

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  • DOI: https://doi.org/10.1007/BF00272394

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