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Expression of the placental form of glutathione S-transferase in pediatric gliomas

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Abstract

Expression of the human placental form of glutathione S-transferase (GST-θ) in pediatric gliomas, consisting of three pilocytic astrocytomas (grade 1), two fibrillary astrocytomas (grade 2), three anaplastic astrocytomas (grade 3), and one glioblastoma multiforme (grade 4), were investigated by immunohistochemical methods. Western blot analysis for GST-θ using proteins extracted from formalin-fixed and paraffin-embedded glioma specimens was performed and compared with the results of immunohistochemistry. Both the immunohistochemical examination and the Western blot analysis of pediatric gliomas revealed that malignant gliomas such as anaplastic astrocytoma and glioblastoma had strong expression of GST-θ while benign gliomas showed weak GST-θ expression.

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Authors and Affiliations

  1. Department of Neurosurgery, Gifu University School of Medicine, 40 Tsukasa-machi, 500, Gifu City, Japan

    Akira Hara, Noboru Sakai, Hiromu Yamada & Shuji Niikawa

  2. Department of Pathology, Gifu University School of Medicine, 500, Gifu City, Japan

    Naoki Yoshimi, Hideki Mori & Kunivasu Shimokawa

Authors
  1. Akira Hara
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  2. Noboru Sakai
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  3. Hiromu Yamada
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  4. Shuji Niikawa
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  5. Naoki Yoshimi
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  6. Hideki Mori
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  7. Kunivasu Shimokawa
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Hara, A., Sakai, N., Yamada, H. et al. Expression of the placental form of glutathione S-transferase in pediatric gliomas. Child's Nerv Syst 9, 142–146 (1993). https://doi.org/10.1007/BF00272262

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  • DOI: https://doi.org/10.1007/BF00272262

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