Abstract
Via recoil activation, carrier-free 18F-labeled acetic acid can be produced by the irradiation of a mixture of glacial acetic acid and potassium fluoride. The labeling yield seems to be high enough to produce this compound with activity amounts suitable for nuclear medical investigation.
Using a mixture of glacial acetic acid and freon-11, 18F-labeled acetic acid could be found. This system is assumed to be more applicable for the production of other 18F-labeled carboxylic acids. Under optimized irradiation conditions we expect to produce some mCi of labeled monofluoroacetic acid.
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Feinendegen, L.E., Stöcklin, G.L.: Entwicklung neuer Radiopharmaka-Stoffwechseluntersuchungen am Herzmuskel durch markierte Fettsäuren, Jahresbericht 77/78 der KFA-Jülich, Jülich 1978, pp. 59–67
Palmer, A.J.: Recoil labelling of fluorine-18 labelled chlorofluoromethanes and tetrafluoromethane. Int. J. Appl. Rad. Isotopes 29, 545 (1978)
Poe, N.D., Robinson, G.D., Jr., MacDonald, N.S.: Myocardial extraction of variously labelled fatty acids and carboxylates. J. Nucl. Med. 14, 440 (1973)
Robinson, G.D. Jr.: Rapid synthesis of high-specific-activity, biologically active 18F-fluoroaliphatic analog compounds. J. Nucl. Med. 14, 446 (1973)
Robinson, Jr., MacDonald, N.S.: Biological dynamics of 18F-and 11C-labelled carboxylates and alcohols. J. Nucl. Med. 14, 446 (1973)
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Donnerhack, A., Sattler, E.L. Production of carrier-free 18F-labeled acetic acid via a recoil labeling method. Eur J Nucl Med 5, 277–279 (1980). https://doi.org/10.1007/BF00271912
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DOI: https://doi.org/10.1007/BF00271912