Summary
The etiology and pathogenesis of Lyme disease are reviewed and the value of the condition as a human model for an infectious etiology of rheumatic disease is discussed. Similarities between Lyme disease and rheumatoid arthritis are considered.
Similar content being viewed by others
References
Malawista SE (1989) Lyme disease. In: McCarty DJ (ed) Arthritis and allied conditions, 11th edn. Lea and Febiger, Philadelphia, pp. 1955–1965
Malawista SE, Steere AC, Hardin JA (1984) Lyme disease: a unique human model for an infectious etiology of rheumatic disease. Yale J Biol Med 57:473–477
Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman GH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE (1983) The early clinical manifestations of Lyme disease. Ann Intern Med 99:76–82
Schlesinger PA, Duray PH, Burke BA, Steere AC (1985) Maternal-fetal transmission of the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med 103:67–68
Kochi S, Johnson RC (1988) Role of immunoglobulin G in killing of Borrelia burgdorferi by the classical complement pathway. Infect Immun 56:314–321
Sigal L, Steere AC, Freeman DH, Dwyer JM (1986) Proliferative responses of mononuclear cells in Lyme disease. Arthritis Rheum 29:761–769
Craft JE, Fischer DK, Shimamoto GT, Steere AC (1986) Antigens of Borrelia burgdorferi recognized during Lyme diseae: appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J Clin Invest 78:934–939
Steere AC, Hardin JA, Malawista SE (1977) Erythema chronicum migrans and Lyme arthritis. Cryoimmunoglobulins and clinical activity of skin and joints. Science 196:1121–1122
Steere AC, Hardin JA, Ruddy S, Mummaw JG, Malawista SE (1979) Lyme arthritis: correlation of serum and cryoglobulin IgM with activity and serum IgG with remission. Arthritis Rheum 2:471–483
Hardin JA, Walker LC, Steere AC, Trumble TC, Tung KSK, Williams RC Jr, Ruddy S, Malawista SE (1979) Circulating immune complexes in Lyme arthritis: detection of the 125I-Clq binding, Clq solid phase and Raji cell assays. J Clin Invest 63:468–477
Hardin JA, Steere AC, Malawista SE (1979) Immune complexes and the evolution of Lyme arthritis: dissemination and localization of abnormal Clq binding activity. N Engl J Med 301:1358–1363
Steere AC, Gibofsky A, Pattarroyo ME, Winchester RJ, Hardin JA, Malawista SE (1979) Chronic Lyme arthritis: clinical and immunogenetic differentiation from rheumatoid arthritis. Ann Intern Med 90:286–291
Kristoferistch W, Mayr WR, Partsch H, Neuman R, Stanek G (1986) HLA-DR in Lyme borreliosis (letter) Lancet II:278
Steere AC, Feld J, Winchester R (1988) Association of chronic Lyme arthritis with increased frequencies of DR4 and 3. Clin Res 36:600A (abstr)
Hardin JA, Steere AC, Malawista SE (1984) The pathogenesis of arthritis in Lyme disease: humoral immune responses and the role of intra-articular immune complexes. Yale J Biol Med 57:589–593
Steere AC, Malawista SE, Hardin JA, Ruddy S, Askenase PW, Andiman WA (1977) Erythema chronicum migrans and Lyme arthritis: the enlarging clinical spectrum. Ann Intern Med 86:685–698
Steere AC, Brinckerhoff CE, Miller DJ, Drinker H, Harris E Jr, Malawista SE (1980) Elevated levels of collagenase and prostaglandin E2 from synovium associated with erosion of cartilage and bone in a patient with chronic Lyme arthritis. Arthritis Rheum 23:591–599
Steere AC, Duray PH, Butcher EC (1988) Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Arthritis Rheum 31:487–495
Johnston YE, Duray PH, Steere AC, Kashgarian M, Buza J, Malawista SE, Askenase PW (1985) Lyme arthritis: spirochetes found in synovial microangiopathic lesions. Am J Pathol 118:26–34
Habicht GS, Beck G, Benach JL, Coleman JL, Leichtling KD (1985) Spirochetes induce human and murine interleukin-1 production. J Immunol 134:3147–3154
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Malawista, S.E. Pathogenesis of Lyme disease. Rheumatol Int 9, 233–235 (1989). https://doi.org/10.1007/BF00271887
Issue Date:
DOI: https://doi.org/10.1007/BF00271887