Summary
While it has been known for some years that there is an association between lentiviruses and slowly progressive joint diseases in ruminants, the realization that the human immunodeficiency virus, the cause of AIDS, is a lentivirus has made this group of virus the focus of a considerable research effort. The manifestations of lentivirus infection in animals are discussed and reference is made to the possibility of using them as models for human rheumatoid arthritis and for AIDS.
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References
Cork LC, Hadlow WJ, Crawford TB, Gorham JR, Piper RC (1974) Infectious leukoencephalomyelitis in young goats. J Infect Dis 129:134–141
Cork LC, Narayan O (1980) The pathogenesis of viral leukoencephalomyelitis-arthritis of goats. I. Persistent viral infection with progressive pathologic changes. Lab Invest 42:596–602
Marsh H (1923) Progressive pneumonia in sheep. J Am Vet Med Assoc 62:458–473
Sigurdsson B (1954) Maedi, a slow progressive pneumonia of sheep: an epizoological and a pathological study. Br Vet J 110:255–270
Palsson PA (1976) Maedi and visna in sheep. In: Kimberlin RH (ed) Slow virus diseases of animal and man. North-Holland, Amsterdam
Gudnadottir M, Palsson PA (1965) Successful transmission of visna by intrapulmonary inoculation. J Infect Dis 115:217–225
Gudnadottir M, Palsson PA (1967) Transmission of maedi by inoculation of a virus grown in tissue culture from maedi affected lungs. J Infect Dis 117:1–6
Gudnadottir M (1974) Visna-maedi in sheep. Progr Med Virol 18:336–349
Jensen R (1974) Diseases of sheep. Lea and Febiger, Philadelphia
Cutlip RC, Lehmkuhl HD, Brogden KA, Bolin SR (1985) Mastitis associated with ovine progressive pneumonia. Am J Vet Res 46:326–328
Kennedy-Stoskopf S, Narayan O, Strandberg JD (1985) The mammary gland is a target organ for infection with caprine arthritis-encephalitis virus. J Comp Pathol 95:609–617
Adams DS, Klevjer-Anderson P, Carlson JL, McQuire TC, Gorham JR (1983) Transmission and control of caprine arthritis-encephalitis virus. Am J Vet Res 44:1670–1675
Cutlip RC, Lehmkuhl HD, Jackson TA (1981) Intrauterine transmission of ovine progressive pneumonia virus. Am J Vet Res 42:1795–1797
Cutlip RC, Lehmkuhl HD (1986) Eradication of ovine progressive pneumonia from sheep flocks. J Am Vet Assoc 188:1026–1027
Cutlip RC, Lehmkuhl HD, Wood RL, Brogden KA (1985) Arthritis associated with ovine progressive pneumonia. Am J Vet Res 46:65–68
Banks KL, Adams DS, MyQuire TC, Carlson J (1983) Experimental infection of sheep by caprine arthritis-encephalitis virus and goats by progressive pneumonia virus. Am J Vet Res 44:2307–2311
Narayan O, Griffin DE, Chase J (1977) Antigenic shift of visna virus in persistently infected sheep. Science 197:376–378
Lutley R, Petursson G, Palsson, PA, Georgsson G, Klein J, Nathanson N (1983) Antigenic drift in visna: virus variation during long term infection of Icelandic sheep. J Gen Virol 64:1433–1440
Stanley J, Bhaduri LM, Narayan O, Clements JE (1986) Topographical rearrangements of visna virus envelope glycoprotein during antigenic drift. J Virol 61:1019–1028
Cutlip RC, Lehmkuhl HD, Brogden KA, Sacks JM (1986) Breed susceptibility to ovine progressive pneumonia (maedi/visna) virus. Vet Microbiol 12:283–288
Crawford TB, Adams DS, Sande RD, Gorham JR, Henson JB (1980) The connective tissue component of the caprine arthritis-encephalitits syndrome. Am J Pathol 100:443–450
Ezaki T, Parisot R, Dudler L, Beya MF, Miyasaka M, Trnka Z (1985) Monoclonal antibodies to surface markers which define functional subsets of sheep T lymphocytes. In: Morris B, Miyasaka M (eds) Immunology of the sheep. Editiones Roche, Basel
Maddox JF, MacKay CR, Brandon MR (1985) Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies. Immunology 55:739–748
Kennedy-Stoskopf S, Zink C, Narayan O (1989) Pathogenesis of ovine lentivirus-induced arthritis: phenotypic evaluation of T lymphocytes in synovial fluid, synovium and peripheral circulation. Clin Immun Immunopathol 52:323–330
Narayan O, Wolinsky JS, Clements JE, Strandberg JD, Griffin DE, Cork LC (1982) Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats. J Gen Virol 59:345–356
Gendelman HE, Narayan O, Molineaux S, Clements JE, Ghotbi Z (1985) Slow persistent replication of lentiviruses: role of macrophages and macrophage precursors in bone marrow. Proc Natl Acad Sci 82:7086–7090
Jolly P, Huso D, Sheffer D, Narayan O (1989) Modulation of lentivirus replication by antibodies. 1. Fc portion of immune immunoglobulin molecule is essential for enhancement of binding and internalization of lentiviruses in macrophages. J Virol 63:1811–1813
Terpstra C, de Boer GF (1973) Precipitating antibodies against maedi-visna virus in experimentally infected sheep. Arch Ges Virusforsch 43:53–62
Houwers DJ, Gielkins ALJ, Schaake J (1982) An indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to maedi-visna virus. Vet Microbiol 7:209–219
Sigurdsson B, Thormar H, Palsson PA (1960) Cultivation of visna virus in tissue culture. Arch Ges Virusforsch 10:368–381
Larsen HJ, Hyllseth B, Krogsrud J (1982) Experimental maedi virus infection in sheep: cellular and humoral immune response during three years following intranasal inoculation. Am J Vet Res 43:384–389
Griffin DE, Narayan O, Adams RJ (1978) Early immune responses in visna, a slow viral disease of sheep. J Infect Dis 138:340–350
Plata F, Autran B, Martins LP, Wain-Hobson S, Raphael M, Mayaud C, Denis M, Guillon J-M, Debre P (1987). AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature 328:348–351
Narayan O, Sheffer D, Clements JE, Tennekoon G (1985) Restricted replication of lentiviruses. Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages. J Exp Med 162:1970–82
Meijer CLM, de Graaff-Reitsma CB, Lafeber GJM, Cats A (1982) In situ localization of lymphocyte subsets in synovial membrane of patients with rheumatoid arthritis with monoclonal antibodies. J Rheumatol 9:359–365
Lindblad S, Klareskog L, Hedfors E, Forsum U, Sundstrom C (1983) Phenotypic characterization of synovial tissue cells in situ in different types of synovitis. Arthritis Rheum 26:1321–1332
Duclos M, Zeidler H, Liman W, Pichler WJ, Rieber P, Peter HH (1982) Characterization of blood and synovial fluid lymphocytes from patients with rheumatoid arthritis and other joint diseases by monoclonal antibodies (OKT series) and acid α-naphthyl esterase staining. Rheumatol Int 2:75–82
Duke O, Panayi GS, Janossy G, Poulter LW, Tidman N (1983) Analysis of T cell subsets in the peripheral blood and synovial fluid of patients with rheumatoid arthritis by means of monoclonal antibodies. Ann Rheum Dis 42:357–361
Joshi VV, Oleske JM, Minnefor AB, Saad S, Klein KM, Singh R, Zabala M, Dadzie C, Simpser M, Rapkin RH (1985) Pathologic pulmonary findings in children with the acquired immunodeficiency syndrome. Human Pathol 16:241–246
Lairmore MD, Poulsson JM, Adducci TA, DiMartini JC (1988) Lentivirus-induced lymphoproliferative disease. Comparative pathogenicity of phenotypically distinct ovine lentivirus strains. Am J Pathol 130:80–90
Itescu S, Brancto LJ, Buxbaum J, Solomon G, Winchester RJ (1988) Sjogren's syndrome associated with HIV infection. Clin Res 36:599A
Rynes RI, Goldenberg D, Olsen R, Hussain M, Veazey J, DiGiacomo R (1987) Acquired immunodeficiency syndrome (AIDS) associated arthritis. Arthritis Rheum 30:S37
Winchester R, Bernstein DH, Fischer HD, Enlow R, Solomon G (1987) The co-occurrence of Reiter's syndrome and acquired immunodeficiency. Ann Intern Med 106:19–26
Espinoza LR, Berman A, Vasey FB, Cahalin C, Nelson R, Germain BF (1988) Psoriatic arthritis and acquired immunodeficiency syndrome. Arthritis Rheum 31:1034–1040
Nathanson N, Panitch H, Palsson PA, Petursson G, Georgsson G (1976) Pathogenesis of visna II. Effect of immunosuppression upon early central nervous system lesions. Lab Invest 35:444–451
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Kennedy-Stoskopf, S. Pathogenesis of lentivirus-induced arthritis. Rheumatol Int 9, 129–136 (1989). https://doi.org/10.1007/BF00271869
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DOI: https://doi.org/10.1007/BF00271869