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Cis- and trans-activity of P22 antirepressor protein against c-repression specified by the closely related Salmonella phages L and Px1

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Summary

The ant product of Salmonella phage P22, synthesized by its immI region, releases when acting in cis replication inhibition for phages P22 and L. When ant product acts in trans on a coinfecting immunity sensitive phage (Thomas-Bertani-experiment as test for release of replication inhibition) full replication ensues only if both superinfecting phages are homologous in the specificities of their immC and immI regions. If these regions are heterologous, differing in immC, immI or in both, the replication of the phage expected to be complemented by ant is inhibited. This inhibition is observed in both L- and Px-lysogenic bacteria and can be released in case of ant - amber phages by action of ant in cis in su +lysogenic bacteria.

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  1. Abt. für Molekulare Genetik im Institut für Mikrobiologie der Gesellschaft für Strahlen- und Umweltforschung mbH München in Göttingen, Grisebachstr. 8, D-3400, Göttingen, Federal Republic of Germany

    Hermann H. Prell

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  1. Hermann H. Prell
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Communicated by F. Stahl

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Prell, H.H. Cis- and trans-activity of P22 antirepressor protein against c-repression specified by the closely related Salmonella phages L and Px1. Molec. Gen. Genet. 168, 323–329 (1979). https://doi.org/10.1007/BF00271503

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  • DOI: https://doi.org/10.1007/BF00271503

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