Rosoxacin distribution in kidney and prostate: experimental studies in dogs

Summary

Concentrations of rosoxacin, a new quinolone derivative, in the renal hilar lymph, renal interstitial fluid, prostatic interstitial fluid, and prostatic secretion were investigated in dogs during constant intravenous infusion. The lymph was obtained by direct cannulation of the lymphatics and the interstitial fluid from small plastic tissue chambers implanted six weeks before the experiments. Renal clearance of rosoxacin was compared to the glomerular filtration rate, as measured by ¹²⁵I-iothalamate clearance, and showed a net reabsorption of rosoxacin. The renal lymph and interstitial fluid concentrations in both kidney and prostate were found to be lower than the simultaneous plasma concentrations, corresponding well with earlier findings for several other antimicrobial agents. However the concentrations in lymph and interstitial fluids were higher than the minimum inhibitory concentrations for most enterobacteriaceae normally encountered in urinary tract infections.