Abstract
A case is reported of methotrexate leukoencephalopathy presenting as an intracerebral rim-enhancing mass lesion of CT scan. The implications of this rare presentation of methotrexate leukoencephalopathy for therapy are discussed.
Similar content being viewed by others
References
Bjorgen JE, Gold LHA (1977) Computed tomographic appearance of methotrexate-induced necrotizing leukoencephalopathy. Radiology 122:377–378
Bleyer WA (1981) Neurologic sequelae of methotrexate and ionizing radiation: a new classification. Cancer Treat Rep [Suppl 1] 65:89–98
Duffner PK, Cohen ME, Brecher ML, Berger P, Parthasarathy KL, Bakshi S, Ettinger LJ, Freeman A (1984) CT abnormalities and altered methotrexate clearance in children with CNS leukemia. Neurology 34:229–233
Gagliano RG, Costanzi JJ (1976) Paraplegia following intrathecal methotrexate. Cancer 37:1663–1668
Geiser CF, Bishop Y, Jaffe N, Furman L, Traggis D, Frei E (1975) Adverse effects of intrathecal methotrexate in children with acute leukemia in remission. Blood 45:189–195
Lui HM, Maurer HS, Vongsvivut S, Conway JJ (1978) Methotrexate encephalopathy: a neuropathologic study. Human Pathol 9:635–648
Meadows AT, Evans AE (1976) Effects of chemotherapy on the central nervous system. Cancer [Suppl 2] 37:1079–1085
McIntosh S, Fischer DB, Rothman SG, Rosenfield N, Lobel JS, O'Brien RT (1977) Intracranial calcifications in childhood leukemia. J Pediatr 91:909–913
Ochs JJ, Berger P, Brecher ML, Sinks LF, Kinkel W, Freeman AI (1980) Computed tomography brain scans in children with acute lymphocytic leukemia receiving methotrexate alone as central nervous system prophylaxis. Cancer 45:2274–2278
Ochs JJ, Parvey LS, Whitaker JN, Bowman WP, Ch'ien L, Campbell M, Coburn T (1983) Serial cranial computed tomography scans in children with leukemia given two different forms of central nervous system therapy. J Clin Oncol 1:793–799
Pederson H, Clausen N (1981) The development of cerebral CT changes during treatment of acute lymphocytic leukemia in childhood. Neuroradiology 22:79–84
Peylan-Ramu N, Poplack DG, Pizzo PA, Adornato BT, Di Chiro G (1978) Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy. N Engl J Med 298:815–818
Shalen PR, Ostrow PT, Glass PJ (1981) Enhancement of the white matter following prophylactic therapy of the central nervous system for leukemia: radiation effects and methotrexate leukoencephalopathy. Radiology 140:409–412
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Poskitt, K.J., Steinbok, P. & Flodmark, O. Methotrexate leukoencephalopathy mimicking cerebral abscess on CT brain scan. Child's Nerv Syst 4, 119–121 (1988). https://doi.org/10.1007/BF00271394
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00271394