Abstract
Medulloblastoma constituted 28% of brain neoplasms among children referred to the Santobono Children's Hospital of Naples from 1973 through October 1984. The authors summarize their experience with 68 cases of medulloblastoma, which were managed with a multimodal institutional protocol involving surgery, chemotherapy and radiation therapy. The evolution of modern management is discussed, and particular attention is directed to the factors affecting the prognosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allen JC, Epstein F (1982) Medulloblastoma and the other primary malignant neuroectodermal tumors of the CNS. The effect of patients' age and extend of disease on prognosis. J Neurosurg 57:446–451
Amador LV (1983) Brain tumors in the young. Thomas, Springfield, Ill, pp 408–413
Ambrosio A (1983) I tumori cerebrali nel bambino. Verduci, Rome, pp 176–183
Berry MP, Jenkin RDT, Keen CW (1981) Radiation treatment for medulloblastoma. A 21-year review. J Neurosurg 55:43–51
Bloom HJG (1979) Adjuvant therapy for residual disease in children with medulloblastoma. Recent Results Cancer Res 68:412–422
Chatty EM, Earle KM (1971) Medulloblastoma. A report of 201 cases with emphasis on histologic variants to survival. Cancer 28:977–983
Choux M, Lena G (1982) Le médulloblastome. In: Société de Neurochirurgie de Langue Française, 32ème Congrès Annuel. Masson, Paris
Dhellemmes P, Demaille MC, Lejeune JP, Baranzelli MC, Combelles G, Torrealba G (1986) Cerebellar medulloblastoma: results of multidisciplinary treatment. Surg Neurol 25:290–294
Gerosa M, Di Stefano E, Olivi A, Carteri A (1980) Multidisciplinary treatment of medulloblastoma. A review of an integrated program (two arm chemotherapy). Child's Brain 6:262–273
Harisiadis L, Chang CH (1977) Medulloblastoma in children: a correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 2:833–841
Hirsch JF, Renier D, Czernichow P, Benveniste L, Pierre Kahn A (1979) Medulloblastoma in childhood. Survival and functional result. Acta Neurochir (Wien) 48:1–15
Hoffman GR, Hendrick EB, Humphreys RP (1976) Metastasis via ventriculoperitoneal shunt in patients with medulloblastoma. J Neurosurg 44:562–566
Jereb B, Sundaresan N, Horten B, Reid A, Galicich JA (1981) Supratentorial recurrences in medulloblastoma. Cancer 15:217–219
Kopelson G, Linggodd RM, Kleinmang GM (1983) Medulloblastoma: the identification of prognostic subgroups and implications for multimodality management. Cancer 53:312–319
Mazza L, Pasqualin A, Dapian R, Donati E (1981) Treatment of medulloblastoma in children: long-term results following surgery, radiotherapy and chemotherapy. Acta Neurochir (Wien) 57:163–175
Mealey J, Hall PV (1977) Medulloblastoma in children: survival and treatment. J Neurosurg 46:56–64
Raimondi AJ, Tomita T (1979) Medulloblastoma in childhood. Acta Neurochir (Wien) 50:127–138
Tae Sung Park, Hoffman HJ, Humphreys P, Becker LE (1983) Medulloblastoma: clinical presentation and management. Experience of the Hospital for Sick Children. J Neurosurg 58:543–552
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Colangelo, M., Daniele, B., Ruggiero, R. et al. Medulloblastoma: a critical approach to the management on the basis of 12 years of experience. Child's Nerv Syst 3, 81–84 (1987). https://doi.org/10.1007/BF00271128
Issue Date:
DOI: https://doi.org/10.1007/BF00271128