Summary
Colicin factors are thought to fall into two taxonomic groups which differ in, amongst other properties, the molecular weight of the plasmid DNA and the host range of the colicin protein. This hypothesis is supported by the plasmids found in 26 colicinogenic strains. Two small Col factors may have arisen from larger factors, judging from similarities between their colicins.
Similar content being viewed by others
References
Davies, J.K., Reeves, P.: Genetics of resistance to colicins in Escherichia coli K-12: cross-resistance among colicins of group B. J. Bact. 123, 96–101 (1975a)
Davies, J.K., Reeves, P.: Genetics of resistance to colicins in Escherichia coli K-12: cross-resistance among colicins of group A. J. Bact. 123, 102–117 (1975b)
Davies, R.W., Simon, M., Davidson, N.: Electron microscope heteroduplex methods for mapping regions of base sequence homology in nucleic acids. In: Methods in enzymology (ed. by L. Grossman and K. Moldave), Vol. 21, pp. 413–428. New York: Academic Press 1971
Frédéricq, P.: Recherches sur les caractères et la distribution des souches productrices de diverses colicines dans les selles normales et pathologiques. Bull. Acad. roy. Med. Belg. 18, 126–139 (1953)
Gratia, J.P.: Résistance à la colicine B chez Escherichia coli. Relations de spécificité entre colicines B, I, V et phage Tl. Etude génétique. Ann. Inst. Pasteur (Paris) 107 (Suppl. 5), 132–151 (1964)
Guerry, P., LeBlanc, D.J., Falkow, S.: General method for the isolation of plasmid deoxyribonucleic acid. J. Bact. 116, 1054–1066 (1973)
Hardy, K.G.: Colicinogeny and related phenomena. Bact. Rev. 39, 464–515 (1975)
Hardy, K.G., Meynell, G.G.: ‘Induction’ of colicin factor E2-P9 by mitomycin C. J. Bact. 112, 1007–1009 (1972)
Hardy, K.G., Meynell, G.G., Downman, J.E., Spratt, B.G.: Two major groups of colicin factors: their evolutionary significance. Molec. gen. Genet. 125, 217–230 (1973)
Hughes, C., Meynell, G. G.: Rapid screening for plasmid DNA. Molec. gen. Genet. 151, 175–179 (1977)
Pugsley, A.P., Reeves, P.: Comparison of colicins B-K260 and D-CA23: purification and characterization of the colicins and examination of colicin immunity in the producing strains. Antimicrob. Agents and Chemotherapy 11, 345–358 (1977)
Timmis, K., Cabello, F., Cohen, S.N.: Utilization of two distinct modes of replication by a hybrid plasmid constructed in vitro from separate replicons. Proc. nat. Acad. Sci. (Wash.) 71, 4556–4560 (1974)
Author information
Authors and Affiliations
Additional information
Communicated by W. Arber
Rights and permissions
About this article
Cite this article
Hughes, V., Le Grice, S., Hughes, C. et al. Two major groups of colicin factors: Their molecular weights. Molec. Gen. Genet. 159, 219–221 (1978). https://doi.org/10.1007/BF00270897
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00270897