Skip to main content
Log in

Double infection of the CNS with herpes simplex and mumps viruses

Serological and ultrastructural studies

  • Original Papers
  • Published:
Child's Nervous System Aims and scope Submit manuscript

Abstract

Clinical, serological and ultrastructural features are described in a case of acute encephalitis. The ultrastructural study of brain biopsy specimens revealed herpes-and paramyxovirus-like particles in neurons and glial cells that were characterized as herpes simplex and mumps viruses by serological study in serum and CSF. Of the few cases previously reported with double encephalitis, this is the only one in which ultrastructural and serological evidence of combined brain infection has been found.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bouteille M, Kalifat SR, Delarue J (1967) Ultrastructural variations of nuclear bodies in human diseases. J Ultrastruct Res 19:474–486

    Google Scholar 

  2. Cappel R, Thiry L, Clinet G (1975) Viral antibodies in the CSF after acute CNS infections. Arch Neurol 32:629–631

    Google Scholar 

  3. Dayan AD (1971) Encephalitis due to simultaneous infection by herpes simplex and measles viruses. J Neurol Sci 14:315–323

    Google Scholar 

  4. Iannetti P, Balducci L, Businco L, et al (1977) Herpetic encephalitis with associated cytomegalovirus infection and myoclonus. Lancet II:1227–1228

    Google Scholar 

  5. Joncas J, Berthiaume HL, McLaughlin B, et al (1976) Herpes encephalitis — rapid diagnosis and treatment with antiviral drugs. J Neurol Sci 28:203–215

    Google Scholar 

  6. Kitamura M, Miyazono J, Mori R, et al (1978) Optical diffraction analysis of electron microscope images of tubular structures found in cells infected with herpes simplex virus type 2. J Gen Virol 41:167–170

    Google Scholar 

  7. Koskiniemi M-L, Vaheri A (1982) Diagnostic value of cerebrospinal fluid antibodies in herpes simplex virus encephalitis. J Neurol Neurosurg Psychiatry 45:239–242

    Google Scholar 

  8. Legg NJ (1967) Virus antibodies in subacute sclerosing panencephalitis: a study of 22 patients. Br Med J 3:350–352

    Google Scholar 

  9. Longson M, Bayley AS, Klapper P (1980) Herpes encephalitis. In: Waterson AP (ed) Recent advances in clinical virology, vol 2. Churchill Livingstone, New York, pp 147–157

    Google Scholar 

  10. Merigan TC (1974) Host defenses against viral disease. N Engl J Med 290:323–329

    Google Scholar 

  11. Neuwelt EA, Clark WK (1978) Clinical aspects of neuro-immunology. Williams & Wilkins, Baltimore, p 223

    Google Scholar 

  12. Notkins AL, Mergenhagen SE, Howard RJ (1976) Effect of virus infection on the function of the immune system. Annu Rev Microbiol 24:525–538

    Google Scholar 

  13. Paula-Barbosa MM, Gray EG (1974) The effect of various fixatives at different pH on synaptic coated vesicles, reticulosomes and cytonet. J Neurocytol 3:471–486

    Google Scholar 

  14. Paula-Barbosa MM, Ruela C, Faria R, et al (1980) Cerebral cortex dendritic degeneration in subacute sclerosing panencephalitis (SSPE). Neurology (Minneap) 30:7–11

    Google Scholar 

  15. Roström B, Link H, Norrby E (1981) Antibodies in oligoclonal immunoglobulins in CSF from patients with acute cerebrovascular disease. Acta Neurol Scand 64:225–240

    Google Scholar 

  16. Shaw CM, Sumi SM (1975) Nonviral intranuclear filamentous inclusions. Arch Neurol 32:428–432

    Google Scholar 

  17. Stroop WG, Baringer JR (1982) Persistent, slow, and latent viral infections. Prog Med Virol 28:1–43

    Google Scholar 

  18. Vandvik B, Nilsen RE, Vartdal F, Norrby E (1982) Mumps meningitis: specific and non-specific antibody responses in the central nervous system. Acta Neurol Scand 65:468–487

    Google Scholar 

  19. Vandvik B, Vardal F, Norrby E (1982) Herpes simplex virus encephalitis: intrathecal synthesis of oligoclonal virus-specific IgG, IgA and IgM antibodies. J Neurol 228:25–38

    Google Scholar 

  20. Yanagisawa N, Toyokura Y, Shiraki H (1975) Double encephalitis with herpes simplex virus and cytomegalovirus in an adult. Acta Neuropathol (Berl) 33:153–164

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rio, M.E., Silva, C.A., Paula-Barbosa, M.M. et al. Double infection of the CNS with herpes simplex and mumps viruses. Child's Nerv Syst 1, 215–218 (1985). https://doi.org/10.1007/BF00270765

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00270765

Key words

Navigation