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Macroamylasemia associated with ulcerative colitis

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Abstract

We describe a very rare case in which macroamylasemia was associated with ulcerative colitis of total colitis type. The patient's serum amylase isozyme pattern by electrophoresis showed a broad abnormal peak toward the side of the positive pole compared with regular salivary and pancreatic fractions. Sephadex G-200 column chromatography showed a sedimentation coefficient of 6.6 S. Amylase activity was bound to IgG. Double diffusion experiments demonstrated that amylase activity could be precipitated in gel by an antibody to the λ chain. Although inflammatory bowel disease is occasionally associated with hyperamylasemia due to pancreatitis, we emphasize that, when hyperamylasemia is recognized in patients with inflammatory bowel disease, macroamylasemia also should be considered.

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Abbreviations

MA :

Macroamylasemia

UC :

Ulcerative colitis

IBD :

Inflammatory bowel disease

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan

    Y. Fujimura, C. Nishishita, J. Uchida & M. Iida

Authors
  1. Y. Fujimura
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  2. C. Nishishita
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  3. J. Uchida
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  4. M. Iida
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Fujimura, Y., Nishishita, C., Uchida, J. et al. Macroamylasemia associated with ulcerative colitis. J Mol Med 73, 95–97 (1995). https://doi.org/10.1007/BF00270584

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  • DOI: https://doi.org/10.1007/BF00270584

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