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Properties and reactivity of immune complexes in rheumatoid synovial fluid

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Summary

Fractionation of immune complexes (IC) from rheumatoid synovial fluid revealed the presence of three different fractions of IC. The largest molecular weight form, fraction I (above 1000 Kdaltons) was predominately composed of IgG and IgM and contained both IgM-RF and IgG-RF. The other IC, fraction II (480 Kdaltons) and fraction III (330 Kdaltons), contained predominately IgG with some IgA and only significant amounts of IgG-RF. All three fractions of IC can bind Clq and stimulate human monocyte prostaglandin E (PGE) production. Fraction I IC bound Clq most readily while fraction III IC were the most effective stimulators of monocyte PGE production. IC stimulation of monocyte PGE production was inhibited by staphylococcus protein A suggesting mediation via activation of Fc receptors. It remains to be determined whether this IC reactivity has any pathologic significance.

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Authors and Affiliations

  1. School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, 08103, Camden, New Jersey, USA

    E. Mochan & T. J. Passon Jr.

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  1. E. Mochan
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  2. T. J. Passon Jr.
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Mochan, E., Passon, T.J. Properties and reactivity of immune complexes in rheumatoid synovial fluid. Rheumatol Int 6, 103–109 (1986). https://doi.org/10.1007/BF00270345

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  • DOI: https://doi.org/10.1007/BF00270345

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