Summary
Five X-linked, recessive alleles were isolated which suppress both the pupal and adult coloration phenotypes of the black mutation. Electron micrographs of shed puparia revealed that the aberrant sclerotization of the black cuticle is also suppressed. Amino acid analysis indicated that suppression is associated with an increased concentration of β-alanine, an amino acid known to be deficient in black. The suppressor locus mapped at the tip of the X, to the right of scute, and intragenic complementation was observed among the alleles.
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References
Hankins GR, Sherald AF (1981) Hydropyrimidine hydrase in D. melanogaster. Drosophila Infom Serv 56:57–58
Hodgetts RB (1972) Biochemical characterization of mutants affecting the metabolism of β-alanine in Drosophila. J Insect Physiol 18:937–947
Hodgetts RB, Choi A (1974) β-Alanine and cuticle maturation in Drosophila, Nature 252:710–711
Hodgetts RB, Knopka RJ (1973) Tyrosine and catacholamine metabolism in wild-type Drosophila and a mutant, ebony. J Insect Physiol 19:1211–1220
Jacobs ME (1974) β-alanine and adaptation in Drosophila. J Insect Physiol 20:859–866
Jacobs ME (1978) β-alanine tanning of Drosophila cuticles and chitin. Insect Biochem 8:37–41
Jacobs ME, Brubaker KK (1963) β-alanine utilization of ebony and non-abony Drosophila melanogaster. Science 139:1282–1283
Jenkins JB (1967) The induction of mosaic and complete dumpy mutants in Drosophila melanogaster with ethyl methanesulfonate. Mutat Res 4:90–92
Lewis EB, Bacher F (1968) Method of feeding ethyl methanesulfonate (EMS) to Drosophila males. Drosophila Inform Ser 43:193
Lindsley DL, Grell EH (1968) Genetic variations of Drosophila melanogaster. Carnegie Inst Washington Publ 627
Plough HH (1927) Black-suppressor — a sex linked gene in Drosophila causing apparent anomalies in crossing over in the second chromosome. Proc Fifth Inter Cong Genet 2:1193–1200
Ross RH, Monroe RE (1972) β-alanine metabolism in the housefly, Musca domestica: Studies on anabolism in the early puparium. J Insect Physiol 18:1593–1597
Sherald AF (1980) Sclerotization and coloration of the insect cuticle. Experientia 36:143–146
Stroman P, Bahn E, Norby S, Sich K (1973) 6-Azauracil induced phenocopies of rudimentary wing mutants and their suppression by a suppressor mutant of rudimentary in Drosophila melanogaster. Hereditas 73:239–246
White, BN (1975) Analysis of t-RNA's in five minute and two suppressor mutants of Drosophila melanogaster. Genetics 80:83
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Communicated by W. Gehring
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Sherald, A.F. Intergenic suppression of the black mutation of Drosophila melanogaster . Molec. Gen. Genet. 183, 102–106 (1981). https://doi.org/10.1007/BF00270146
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DOI: https://doi.org/10.1007/BF00270146