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The effect of nitrosoguanidine upon DNA synthesis in vitro

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Summary

Both the polymerase and the exonuclease activities of DNA polymerase III* are inactivated by treatment with nitrosoguanidine. The treatment of the DNA template with the mutagen does not affect the template in supporting DNA synthesis. No effect of nitrosoguanidine upon fidelity of replication in vitro was detected.

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Authors and Affiliations

  1. Department of Biological Sciences, Stanford University, 94305, Stanford, California, USA

    Alfonso Jiménez-Sánchez

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  1. Alfonso Jiménez-Sánchez
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Communicated by B.A. Bridges

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Jiménez-Sánchez, A. The effect of nitrosoguanidine upon DNA synthesis in vitro. Molec. Gen. Genet. 145, 113–117 (1976). https://doi.org/10.1007/BF00269582

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  • DOI: https://doi.org/10.1007/BF00269582

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