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Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L.

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Abstract

The dihydrofuroacridone, rutacridone, is the main alkaloid in tissue cultures of Ruta graveolens L. strain R-19. The biosynthesis of this particular acridone alkaloid was investigated by using calluses and suspension cultures of strain R-19. Anthranilic acid is specifically incorporated into ring A of rutacridone. Some further evidence was provided that acetate via a polyketide is involved in acridone biosynthesis. Mevalonic acid gave a poor incorporation into rutacridone. Thus the origin of the isopropyldihydrofuran moiety of the investigated alkaloid is still obscure.

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Authors and Affiliations

  1. Institut für Biochemie der Pflanzen, Akademie der Wissenschaften der DDR, DDR-4010 Halle (Saale), Weinberg 3, GDR

    A. Baumert, G. Krauss, M. Hieke & D. Gröger

  2. K. A. Timiriazev Institute of Plant Physiology, Academy of Sciences of the USSR, 127 276, Moscow, USSR

    I. N. Kuzovkina

Authors
  1. A. Baumert
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  2. I. N. Kuzovkina
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  3. G. Krauss
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  4. M. Hieke
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  5. D. Gröger
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Baumert, A., Kuzovkina, I.N., Krauss, G. et al. Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L.. Plant Cell Reports 1, 168–171 (1982). https://doi.org/10.1007/BF00269190

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  • DOI: https://doi.org/10.1007/BF00269190

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