Summary
Twenty-four patients receiving combination chemotherapy including cisplatin at a dosage of 50 mg/m2 were entered on this antiemetic randomized open cross-over study. High-dose dexamethasone (DXM) (regimen A) was compared with the combination of DXM and high doses of metoclopramide (MCP) (regimen B). Five patients (20%) treated with regimen A and 13 (54%) treated with regimen B suffered neither hausea nor vomiting (P<0.05). Regimen B was found to be significantly more effective than regimen A for all the parameters of evaluation considered. No severe side-effects were observed.
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Cognetti, F., Pinnaro, P., Carlini, P. et al. Improved control of cisplatin-induced emesis with a metoclopramide-dexamethasone combination. Cancer Chemother. Pharmacol. 13, 235–237 (1984). https://doi.org/10.1007/BF00269037
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DOI: https://doi.org/10.1007/BF00269037