Summary
Twenty-seven patients with liver metastases from colorectal carcinoma were treated with 5-fluorouracil, adriamycin, and mitomycin C (FAM) by hepatic artery infusion (HAI) every 2–3 months for a maximum of eight courses. Median survival for all patients was 22 months. Toxicity was acceptable and consisted in severe myelosuppression (8%), duodenal ulceration (8%), moderate nausea and vomiting (50%), and alopecia (100%). HAI with FAM is feasible and may have an impact on survival. Further studies are needed to determine the role of HAI, which may be of potential benefit to a substantial number of patients with metastatic colorectal carcinoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Almersjö O, Bengmark S, Rudenstam CM, Hafstrom LD, Nilsson LAV (1972) Evaluation of hepatic dearterialization in primary and secondary cancer of the liver. Am J Surg 124: 5
Douglass CC (1979) Improved survival in liver metastases from colorectal carcinoma following periodic arterial infusions with mitomycin C, 5-fluorouracil, adriamycin, velban and vincristine. Proc Am Soc Clin Oncol 20: 431
Ensminger WD, Gyves JW (1983) Regional chemotherapy of neoplastic disease. Pharmacol Ther 21: 277
Ensminger WD, Niederhuber J, Gyves J, Trall J, Cozzi E, Doan K (1982) Effective control of liver metastases from colon cancer with an implanted system for hepatic arterial chemotherapy. Proc Am Soc Clin Oncol 1: 94
Garnick MB, Ensminger WD, Israel M (1979) A clinical-pharmacological evaluation of hepatic arterial infusion of adriamycin. Cancer Res 39: 4105
Grage TB, Vassilopoulos PP, Shingleton WW, Jubert AV, Elias EG, Aust JB, Moss SE (1979) Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases from colorectal cancer: a Central Oncology Group study. Surgery 86: 550
Haller DG, Woolley PV, Macdonald JS, Smith LF, Schein PS (1978) Phase II trial of 5-fluorouracil, adriamycin and mitomycin-C in advanced colorectal cancer. Cancer Treat Rep 62: 563
Jaffe BM, Donegan WL, Watson F, Spratt JS (1968) Factors influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 127: 1
Kemeny N, Daly JM, Oderman P, Shike M (1983) Hepatic infusion chemotherapy for metastatic colorectal carcinoma, results and complications. Proc Am Soc Clin Oncol 2: 123
Koudahl G, Funding J (1972) Hepatic artery ligation in primary and secondary hepatic cancer. Acta Chir Scand 138: 289
Levine AW, Donegan WL, Irwin M (1982) Adenocarcinoma of the colon with hepatic metastases. JAMA 247: 2809
Oxley EM, Ellis H (1969) Prognosis of carcinoma of the large bowel in the presence of liver metastases. Br J Surg 56: 149
Patt YZ, Wallace S, Freireich EJ, Chuang VP, Hersh EM, Mavliget GM (1981) The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver. Lancet 2: 349
Schein PS, Kisner D, Mac Donald JS (1975) Chemotherapy of large intestinal carcinoma: Current results and future prospects. Cancer 35: 1074
Wood CB, Gillis CR, Blumgart LH (1976) A retrospective study of the natural history of patients with liver metastases form colorectal cancer. Clin Oncol 2: 285
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wils, J., Schlangen, J. & Naus, A. Phase II study of hepatic artery infusion with 5-fluorouracil, adriamycin, and mitomycin C (FAM) in liver metastases from colorectal carcinoma. Cancer Chemother. Pharmacol. 13, 215–217 (1984). https://doi.org/10.1007/BF00269032
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00269032