Summary
Salmonella typhimurium mutants have been isolated in which phage P22 fails to establish lysogeny. These appear to be defective in cAMP metabolism. A phage mutation overcoming the bacterial defect has been mapped between gene c 1 and gene 12.
Similar content being viewed by others
References
Berkowitz, D.: D-mannitol utilization in Salmonella typhimurium. J. Bact. 105, 232–240 (1971)
Gough, M., Levine, M.: The circularity of the phage P22 linkage map. Genetics 58, 161–169 (1968)
Grabnar, M., Hartman, P. E.: MG 40 phage, A transducing phage related to P22. Virology 34, 521–530 (1968)
Grodzicker, T., Arditti, R. R., Eisen, H.: Establishment of repression by lambdoid phage in catabolite activator protein and adenylate cyclase mutants of Escherichia coli. Proc. nat. Acad. Sci. (Wash.) 69, 366–370 (1972)
Hong, J.-S., Smith, G. R., Ames, B. N.: Adenosine 3′:5′-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proc. nat. Acad. Sci. (Wash.) 68, 2258–2262 (1971)
Pastan, I., Perlman, R. L.: Cyclic adenosine monophosphate in bacteria. Science 169, 339–344 (1970)
Perlman, R. L., Pastan, I.: Pleiotropic deficiency of carbohydrate utilisation in adenyl cyclase deficient mutant of Escherichia coli. Biochem. biophys. Res. Commun. 37, 151–157 (1969)
Rao, R. N.: Bacteriophage P22 controlled exclusion in Salmonella typhimurium. J. molec. Biol. 35, 607–622 (1968)
Rao, R. N., Raj, C. V. S.: Isolation of Salmonella typhimurium mutants affecting the plaque morphology of phage P22. Molec. gen. Genet. 113, 240–243 (1971)
Smith, H. O., Levine, M.: A phage P22 gene controlling integration of prophage. Virology 31, 207–216 (1967)
Walker, J. R., Ussery, C. L., Allen, J. S.: Bacterial cell division regulation: Lysogenisation of conditional cell division lon- mutants of Escherichia coli by bacteriophage lambda. J. Bact. 113, 1326–1332 (1973)
Author information
Authors and Affiliations
Additional information
Communicated by O. Siddiqi
Rights and permissions
About this article
Cite this article
Rao, R.N., Raj, C.V.S. Salmonella typhimurium mutants affecting establishment of lysogeny. Molec. Gen. Genet. 125, 119–123 (1973). https://doi.org/10.1007/BF00268864
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00268864