Summary
Zn++ at an optimum concentration of 5×10−4 M caused a two fold stimulation in the level of alcohol dehydrogenase (ADH) induced by anaerobic conditions. Isozymes specified by different genes and alleles show disproportionate increases in activity, such that, unequal representation of gene products while not eliminated, is invariably reduced by Zn++ treatment. Thus in the case of alleles at the Adh-1 locus, there was a greater increase in the protein subunit specified by the Adh-1S allele. From previous work (Fischer and Schwartz, 1973) this protein is known to have a reduced affinity for Zn++. This suggests that zinc availability during ADH induction is limiting and may provide an alternative to the cis-linked regulatory gene model proposed by Schwartz (1971) to explain the unequal expression of genes and alleles.
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Communicated by G. Melchers
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Pryor, A., Marshall, D.R. Zn++ stimulation of the induction of alcohol dehydrogenase by anaerobiosis in roots of Zea mays L.. Molec. Gen. Genet. 157, 47–51 (1977). https://doi.org/10.1007/BF00268686
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DOI: https://doi.org/10.1007/BF00268686