Molecular and General Genetics MGG

, Volume 135, Issue 3, pp 245–255 | Cite as

A meiotic effect of a mutator gene in Drosophila melanogaster

  • J. R. Gold
  • M. M. Green


Two new parameters of the third chromosome mutator gene, mu, in Drosophila melanogaster are described. The mutator significantly alters both meiotic chromosome disjunction and crossing over in females, but not in males. In meiotic phenotype, the mutator resembles several recently described “meiotic” mutants of D. melanogaster. However, previous studies have demonstrated that the mutator also functions premeiotically. The mutator appears to be a unique mutant which functions exclusively in females during both mitotic and meiotic cell divisions.


Cell Division Mutator Gene Meiotic Chromosome Meiotic Cell Unique Mutant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Coukell, M. B., Yanofsky, C.: Increased frequency of deletions in DNA polymerase mutants of Escherichia coli. Nature (Lond.) 228, 633–635 (1970)CrossRefGoogle Scholar
  2. Creighton, H. B., McClintock, B.: A correlation of cytological and genetical crossing over in Zea mays. Proc. nat. Acad. Sci. (Wash.) 17 492–497 (1931)CrossRefGoogle Scholar
  3. Drake, J. W., Allen, E. F., Forsberg, F. A., Preparata, R. M., Greening, E. O.: Genetic control of mutation rates in bacteriophage T4. Nature (Lond.) 221, 1128–1132 (1969)CrossRefGoogle Scholar
  4. Gold, J. R.: Genetic studies of a mutator gene in Drosophila melanogaster. Doctoral dissertation; University of California, Davis (1973)Google Scholar
  5. Gold, J. R., Green, M. M.: Mu-A mutator gene in Drosophila melanogaster. Dros. Inform. Serv., 50, 86 (1973)Google Scholar
  6. Gowen, M. S., Gowen, J. W.: Complete linkage in Drosophila melanogaster. Amer. Naturalist 56, 286–288 (1922)CrossRefGoogle Scholar
  7. Green, M. M.: The genetics of a mutator gene in Drosiphila melanogaster. Mutation Res. 10, 353–363 (1970)CrossRefGoogle Scholar
  8. Green, M. M.: Some observations and comments on mutable and mutator genes in Drosophila. Genetics Suppl. 73, 187–194 (1973)Google Scholar
  9. Green, M. M., Lefevre, Jr., G.: The cytogenetics of mutator gene-induced X-linked lethals in Drosophila melanogaster. Mutation Res. 16, 59–64 (1972)CrossRefGoogle Scholar
  10. Hall, J. C.: Non-independence of primary non-disjunction for the sex and fourth chromosomes in Drosophila melanogaster. Dros. Inform. Serv. 45, 160 (1970)Google Scholar
  11. Hall, J. D.: The failure of two alleles of c(3)G to increase frequencies of X-linked lethals. Dros. Inform. Serv. 47, 62 (1971)Google Scholar
  12. Hall, J. D.: Chromosome segregation influenced by two alleles of the meiotic mutant c(3)G in Drosophila melanogaster. Genetics 71, 367–400 (1972)PubMedGoogle Scholar
  13. Hinton, C. W.: Enhancement of recombination associated with the c(3)G mutant of Drosophila melanogaster. Genetics 53, 157–164 (1966)PubMedPubMedCentralGoogle Scholar
  14. Lewis, E. B.: Location of c(3)G in the salivary-gland chromosomes. Dros. Inform. Serv. 22, 72–73 (1948)Google Scholar
  15. Lindsley, D. L., Grell, E. H.: Genetic variations of Drosophila melanogaster. Carnegie Inst. Wash. Publ. 627 (1968)Google Scholar
  16. Lindsley, D. L., Sandler, L., Nicoletti, B., Trippa, G.: Genetic control of recombination in Drosophila. In: Replication and recombination of genetic material (W. J. Peacock and R. D. Brock, eds.), p. 253–276, Canberra: Australian Academy of Science 1968Google Scholar
  17. Sandler, L., Lindsley, D. L.: Some observations on the study of the genetic control of meiosis in Drosophila melanogaster. Genetics 78, 289–297 (1974)PubMedPubMedCentralGoogle Scholar
  18. Sandler, L., Lindsley, D. L., Nicoletti, B., Trippa, G.: Mutants affecting meiosis in natural populations of Drosophila melanogaster. Genetics 60, 525–558 (1968)PubMedPubMedCentralGoogle Scholar
  19. Speyer, J. F.: Mutagenic DNA polymerase. Biochem. biophys. Res. Commun. 21, 6–8 (1965)CrossRefGoogle Scholar
  20. Stern, C.: Zytologische genetische Untersuchungen als Beweise für die Morganische Theorie des Faktorenaustausches. Biol. Zbl. 51, 547–587 (1931)Google Scholar
  21. Stern, H., Hotta, Y.: DNA metabolism during pachytene in relation to crossingover. Genetics 78, 227–235 (1974)PubMedPubMedCentralGoogle Scholar
  22. Stevens, W. L.: Accuracy of mutation rates. J. Genet. 43, 301–307 (1942)CrossRefGoogle Scholar
  23. Weinstein, A.: The theory of multiple-strand crossing over. Genetics 21, 155–199 (1936)PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. R. Gold
    • 1
    • 2
  • M. M. Green
    • 1
  1. 1.Department of GeneticsUniversity of CaliforniaDavisU.S.A.
  2. 2.Department of Animal ScienceUniversity of CaliforniaDavisU.S.A.

Personalised recommendations