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Evidence for a common component in kinetically distinct transport systems of Saccharomyces cerevisiae

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Summary

Two lines of evidence suggest that amino acid transport systems and the methylamine/ammonia transport system of Saccharomyces cerevisiae may share a common component or components.

  1. 1.

    Mutant strains have been derived which are defective in transport activity for methylamine and for amino acids. A single pleiotropic mutation appears to be responsible for the observed reduction in the various transport activities.

  2. 2.

    Transport systems for amino acids and for methylamine are sensitive to a similar degree to inhibition by proton conducting uncouplers, ATPase inhibitors, and ionophores.

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Authors and Affiliations

  1. Department of Biochemistry, University of Minnesota, 435 Delaware St. S.E., 55455, Minneapolis, Minnesota, USA

    Robert J. Roon, Gail M. Meyer & Fred S. Larimore

Authors
  1. Robert J. Roon
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  2. Gail M. Meyer
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  3. Fred S. Larimore
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Additional information

Communicated by F. Kaudewitz

This work was supported in part by Research Grant GM 23135 from the National Institute of General Medical Sciences

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Roon, R.J., Meyer, G.M. & Larimore, F.S. Evidence for a common component in kinetically distinct transport systems of Saccharomyces cerevisiae . Molec. Gen. Genet. 158, 185–191 (1977). https://doi.org/10.1007/BF00268312

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  • DOI: https://doi.org/10.1007/BF00268312

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