Summary
A Bacillus subtilis intracellular serine protease is homologous in sequence to an extracellular serine protease from the same strain, indicating the presence of two related structural genes in the Bacillus subtilis genome.
References
Badr, F.M., Lovkin, P.A., Lehman, H.: Haemoglobin P-Nilotic, containing a β-δ chain. Nature (Lond.) New Biol. 242, 107–110 (1973)
Furano, A.V.: The elongation factor Tu coded by the tuf A gene of Escherichia coli K12 is almost identical to that coded by the tuf B gene. J. biol. Chem. 252, 2154–2158 (1977)
Glenn, A.R.: Production of extracellular proteins by bacteria. Ann. Rev. Microbiol. 30, 41–62 (1976)
Haën, C. de, Swanson, E., Teller, D.C.: The evolutionary origin of proinsulin. Amino acid sequence homology with the trypsinrelated serine proteases detected and evaluated by new statistical methods. J. molec. Biol. 106, 639–611 (1976)
Kurihara, M., Markland, S., Smith, E.L.: Subtilisin Amylosacchariticus. III. Isolation and sequence of the chymotryptic peptides and the complete amino acid sequence. J. biol. Chem. 247, 5619–5631 (1972)
Leighton, T.J., Doi, R.H., Warren, R.A.J., Kelln, R.A.: The relationship of serine protease activity to RNA polymerase modification and sporulation in Bacillus subtilis. J. molec. Biol. 76, 103–122 (1973)
Markland, F.S., Smith, E.L.: Subtilisins: primary structure, chemical and physical properties. In: Enzymes (P. Boyer, ed.), Vol. 3, pp. 561–608. New York-London: Academic Press 1971
Millet, J., Larribe, M., Aubert, J.-P.: Mutant thermosensible de B. subtilis affectè dans le sporulation et la serylprotease extracellulaire. Biochimie 58, 109–117 (1976)
Ohno, S.: Evolution by gene duplication. New York: Springer 1970
Piggot, P.J., Coote, J.G.: Genetic aspects of bacterial endospore formation. Bact. Rev. 40, 908–962 (1976)
Stepanov, V.M., Strongin, A.Ya., Izotova, L.S., Abramov, Z.T., Lyublinskaya, L.A., Ermakova, L.M., Baratova, L.A., Belyanova, L.P.: Intracellular serine protease from Bacillus subtilis. Structural comparison with extracellular serine proteases-subtilisins. Biochem. biophys. Res. Commun. 77, 298–305 (1977)
Strongin, A.Ya., Abramov, Z.T., Levin, E.D., Stepanov, V.M.: The multiple forms of the Novo type subtilisin. Bioorganicheskaya Khimiya 1, 1441–1448 (1975) [in Russian]
Strongin, A.Ya., Izotova, L.S., Abramov, Z.T., Gorodetsky, D.I., Ermakova, L.M., Baratova, L.A., Belyanova, L.P., Stepanov, V.M.: Intracellular serine protease of Bacillus subtilis. Sequence homology with extracellular subtilisins. J. Bact. (1978) in press
Yanofsky, C., Li, S.S.-L., Horn, V., Rowe, J.: Structure and properties of a hybrid tryptophan synthetase α chain produced by genetic exchange between Escherichia coli and Salmonella typhimurium. Proc. nat. Acad. Sci. (Wash.) 74, 286–290 (1977)
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Communicated by H.G. Wittmann
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Strongin, A.Y., Izotova, L.S., Abramov, Z.T. et al. Two related structural genes coding two homologous serine proteases in the Bacillus subtilis genome. Molec. Gen. Genet. 159, 337–339 (1978). https://doi.org/10.1007/BF00268271
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DOI: https://doi.org/10.1007/BF00268271