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Molecular and General Genetics MGG

, Volume 146, Issue 2, pp 161–165 | Cite as

Effect of tra mutations on F factor-specified immunity to lethal zygosis

  • R. A. Skurray
  • N. Willetts
  • P. Reeves
Article

Summary

Hfr, F+, and F-prime cells are, unlike F cells, insensitive to an excess of Hfr donor cells, indicating that there is an F factor mediated immunity to lethal zygosis (Ilz). Results with Flac episomes carrying traJ, traS or various polar mutations in the tra region indicate that this immunity is independent of surface exclusion, of traJ control, and of all known genes within the tra operon. However, analysis of a series of strains with deletions in the F factor, extending from the right into the tra region, suggests that a gene for immunity to lethal zygosis is located within the tra region. We therefore conclude that Ilz is genetically complex, and present a hypothesis to account for these results.

Keywords

Donor Cell Mediate Immunity Polar Mutation Surface Exclusion Lethal Zygosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • R. A. Skurray
    • 1
    • 2
  • N. Willetts
    • 1
    • 2
  • P. Reeves
    • 1
    • 2
  1. 1.Department of MicrobiologyUniversity of Adelaide
  2. 2.Department of Molecular BiologyUniversity of EdinburghScotland

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