Molecular and General Genetics MGG

, Volume 146, Issue 2, pp 133–137 | Cite as

Cytoplasmic inheritance of antimycin A resistance in Saccharomyces cerevisiae

  • Georg Michaelis


Three antimycin resistant mutants of Saccharomyces cerevisiae are characterized genetically. The mutations have been shown to be cytoplasmically inherited by four criteria. The phenotype persists in diploids formed by a cross with a ρ0 strain of yeast of the opposite mating type. Diploids heterozygous for the antimycin marker, however, show segregation of the resistance and sensitivity during mitosis. Tetrad analysis indicated a non-Mendelian segregation (4:0 and 0:4) of the mutations. The antimycin marker can be eliminated by ethidium bromide treatment under conditions that should have deleted all of the mitochondrial DNA.


Bromide Ethidium Ethidium Bromide Saccharomyces Cerevisiae Saccharomyces 
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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Georg Michaelis
    • 1
  1. 1.Physiologisch-Chemisches Institut der Universität WürzburgWürzburgFederal Republic of Germany

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