Summary
Crossing over has been studied with mutants which flank the centromere of chromosome 3 in Drosophila melanogaster. Coefficients of coincidence greater than one were obtained. Putative double crossovers were recovered for genetic intervals whose genetic length is less than one centimorgan. It is suggested that gene conversion rather than conventional double crossing over accounts for the negative interference observed.
Similar content being viewed by others
References
Bole-Gowda, B.N., Perkins, D.D., Strickland, W.M.: Crossing-over and interference in the centromere region of linkage group I of Neurospora. Genetics 47 1243–1252 (1962)
Chovnick, A., Ballantyne, G.H., Baillie, D.L., Holm, D.G.: Gene conversion in higher organisms: Half-tetrad analysis of recombination within the rosy cistron of Drosophila melanogaster. Genetics 66, 315–329 (1970)
Chovnick, A., Ballantyne, G.H., Holm, D.G.: Studies on gene conversion and its relationship to linked exchange in Drosophila melanogaster. Genetics 69, 179–209 (1971)
Denell, R. E. Homoesis in Drosophila. I. Complementation studies with revertants of Nasobemia. Genetics 75, 279–297 (1973)
Fogel, S., Hurst, D.D., Mortimer, R.K.: Gene conversion in unselected tetrads from multipoint crosses. Stadler symp. 122; 89–110 (1971)
Fogel, S., Mortimer, R.K.: Recombination in yeast. Ann. Rev. Genet. 5, 219–236 (1971)
Gehring, W.: Bildung eines vollständigen Mittelbeines mit Sternopleura in der Antennenregion bei der Mutante Nasobemia (Ns) von Drosophila melanogaster. Arch. Klaus-Stift. Vererb.-Forsch. 41, 44–54 (1966)
Graubard, M.A.: Temperature effect on interference and crossing over. Genetics 19, 83–94 (1934)
Hawthorne, D.C. and Mortimer, R.K.: Chromosome mapping in Saccharomyces: centromere linked genes. Genetics 45, 1085–1110 (1960)
Hurst, D.D., Fogel, S., Mortimer, R.K.: Conversion-associated recombination in yeast. Proc. nat. Acad. Sci. (Wash.) 69, 101–105 (1972)
Lindsley, D.L., Grell, E.H.: Genetic variations in Drosophila melanogaster. Carnegie Inst. Wash. Publ. No. 627 (1968)
Morgan, T.H., Sturtevant, A.H., Bridges, C.B.: The genetics of Drosophila. Bibl. genet. 2, 1–262 (1925)
Søgaard, B.: The localization of eceriferum loci in barley III. Three point tests of genes on chromosome 1 in barley. Hereditas 76, 41–48 (1974)
Schultz, J., Redfield, H.: Interchromosomal effects on crossing over in Drosophila. Cold Spr. Harb. Symp. quant. Biol. 16, 175–197 (1971)
Stadler, D.R.: Double crossing over in Neurospora. Genetics 41, 623–630 (1956)
Stadler, D.R.: The mechanism of intragenic recombination. Ann. Rev. Genet. 7, 113–127 (1973)
Stevens, W.L.: The analysis of interference. J. Genet. 32, 51–64 (1936)
Author information
Authors and Affiliations
Additional information
Communicated by Ch. Auerbach
Rights and permissions
About this article
Cite this article
Green, M.M. Conversion as a possible mechanism of high coincidence values in the centromere region of Drosophila . Molec. Gen. Genet. 139, 57–66 (1975). https://doi.org/10.1007/BF00267995
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00267995