Summary
In a rif S/rifR heterodiploid strain of E. coli, a 4 minute pulse of rifampicin can induce a prolonged (>60 min) increase in the rate of synthesis of the RNA polymerase subunits, β and β′. The application of a constraint on the fidelity of protein synthesis during, but not after, the rifampicin pulse partially arrests the development of this capacity for subunit synthesis. I discuss the implications of these findings in relation to the control of the ββ′ operon in E. coli.
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Communicated by E. Bautz
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Tittawella, I.P.B. Rifampicin-induced protein synthesis: A pre-requisite for increased expression of the ββ′ operon in Escherichia coli . Molec. Gen. Genet. 146, 79–83 (1976). https://doi.org/10.1007/BF00267985
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DOI: https://doi.org/10.1007/BF00267985