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The dependence of cytosole protein biosynthesis resistance to cycloheximide in yeast on changes in mitochondrial activity

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Summary

ϱ− mutations induced in wide range of yeast strains caused an increase in the resistance to cycloheximide of the protein biosynthesis system. Similar effect may be obtained also after the addition to the medium of specific mitochondrial inhibitors as chloramphenicol, erythromycin and ethidium bromide as well as in the presence of high concentrations of glucose. However in strictly anaerobic conditions this specific increase did not appear. It was found, that the increase of the resistance of cytosole ribosomes to cycloheximide is related to changes in mitochondrial activity.

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Authors and Affiliations

  1. Department of Genetics Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland

    Tomasz Biliński & Witold J. Jachymczyk

  2. Department of Microbiology, Institute of Botany and Biochemistry, University of Wrocław, Wrocław, Poland

    Zbigniew Kotylak

Authors
  1. Tomasz Biliński
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  2. Witold J. Jachymczyk
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  3. Zbigniew Kotylak
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Communicated by F. Kaudewitz.

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Biliński, T., Jachymczyk, W.J. & Kotylak, Z. The dependence of cytosole protein biosynthesis resistance to cycloheximide in yeast on changes in mitochondrial activity. Molec. Gen. Genet. 129, 243–248 (1974). https://doi.org/10.1007/BF00267916

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  • DOI: https://doi.org/10.1007/BF00267916

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