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Different photodynamic action of proflavine and methylene blue on bacteriophage

I. Host cell reactivation of Serratiaphage kappa

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Summary

Photodynamically induced DNA damage in Serratiaphase ϰ may be repaired by the host cell. The extent of this host cell reactivation (HCR) depends on the photosensitizing dye used: HCR of proflavine+visible light induced DNA damage appears to be more efficient than the one of DNA damage induced by methylene blue+visible light. This significant difference in HCR is not due to a preferential inhibition of the enzymes of DNA dark repair by either one of the dyes injected into the host cell along with the phage's genome.

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Authors and Affiliations

  1. Institut für Mikrobiologie, J.-W. Goethe-Universität Frankfurt a. M., Germany

    Martin Brendel

  2. Department of Biology, York University, Toronto, Canada

    Martin Brendel

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  1. Martin Brendel
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Communicated by F. Kaudewitz

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Brendel, M. Different photodynamic action of proflavine and methylene blue on bacteriophage. Molec. Gen. Genet. 108, 303–311 (1970). https://doi.org/10.1007/BF00267767

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  • DOI: https://doi.org/10.1007/BF00267767

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