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Genetics of oxidative phosphorylation: Allelism studies of mitochondrial loci in the PHO1—OLI2 region of the genome

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Summary

In a search for new aerobic-growth deficiency mutations affecting mitochondrial energy-conservation two mit − mutations, namely pho-8 and pho-9, have been isolated.

The two mutations are allelic with each other, but not allelic with the previously known pho1 mutations although close linkage is indicated.

Allelism studies define three distinct PHO loci clustered in this region which also includes the drugresistance loci OSS1, OLI2 and OLI4. The existence of phenotypically-distinct markers makes the region amenable to fine-structure mapping.

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Author notes

  1. Mark G. Darlison

    Present address: Institut Curie-Biologie, Centre Universitaire, Batiment 110, F-91405, Orsay, France

  2. William E. Lancashire

    Present address: Department of Biochemistry, Imperial College, South Kensington, SW7 2AZ, London, Great Britain

Authors and Affiliations

  1. Department of Chemistry and Molecular Sciences, University of Warwick, CV4 7AL, Coventry, Great Britain

    Mark G. Darlison & William E. Lancashire

Authors
  1. Mark G. Darlison
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  2. William E. Lancashire
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Communicated by F. Kaudewitz

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Darlison, M.G., Lancashire, W.E. Genetics of oxidative phosphorylation: Allelism studies of mitochondrial loci in the PHO1—OLI2 region of the genome. Molec. Gen. Genet. 180, 227–229 (1980). https://doi.org/10.1007/BF00267374

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  • DOI: https://doi.org/10.1007/BF00267374

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