Summary
Ribosomes from the thiostrepton-resistant mutant MJ1 of Bacillus megaterium completely lack a protein designated BM-L11. When assayed in vitro, such ribosomes show an impaired ability to hydrolyse GTP in the presence of the elongation factor EF-G and are unable to support the synthesis of (p)ppGpp in response to the stringent factor. Restoration of both these activities can be achieved by re-addition of either protein BM-L11 or its serological homologue from Escherichia coli, protein L11, implying that these two proteins are related functionally as well as immunologically.
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Communicated by E. Bautz
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Stark, M.J.R., Cundliffe, E., Dijk, J. et al. Functional homology between E. coli ribosomal protein L11 and B. megaterium protein BM-L11. Molec. Gen. Genet. 180, 11–15 (1980). https://doi.org/10.1007/BF00267346
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DOI: https://doi.org/10.1007/BF00267346