Advertisement

Rheumatology International

, Volume 7, Issue 1, pp 7–11 | Cite as

Clinical significance of U1-RNP immune complexes in mixed connective tissue disease and systemic lupus erythematosus

  • N. Negoro
  • Y. Kanayama
  • T. Takeda
  • K. Amatsu
  • S. Koda
  • Y. Inoue
  • T. Kim
  • M. Okamura
  • T. Inoue
Originals

Summary

We measured U1-RNP: anti-U1-RNP immune complexes (U1-RNP ICs) in patients with mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) to examine the clinical significance of circulating U1-RNP ICs. The level of U1-RNP ICs in 11 patients with MCTD was significantly higher than that in 22 normal subjects and there was a close correlation between the level of U1-RNP ICs and the clinical disease activity index of MCTD. In contrast, the level of U1-RNP ICs in 31 patients with SLE was not significantly higher than that in normal subjects and that was not correlated with the clinical disease activity index of SLE or the renal histologic activity index of lupus nephritis. We conclude that U1-RNP ICs are present in sera of patients with MCTD and SLE, and that the level of U1-RNP ICs may be closely associated with clinical disease activity in patients with MCTD.

Key words

U1-ribonucleoprotein Immune complexes Mixed connective tissue disease Systemic lupus erythematosus 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Mattioli M, Reichlin M (1971) Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera. J Immunol 107:1281–1290Google Scholar
  2. 2.
    Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR (1972) Mixed connective tissue disease — an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen. Am J Med 52:148–159Google Scholar
  3. 3.
    Tan EM (1982) Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. Adv Immunol 33:167–240Google Scholar
  4. 4.
    Lerner MR, Steitz JA (1979) Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci USA 76:5495–5499Google Scholar
  5. 5.
    Conner GE, Nelson D, Wisniewolski R, Lahita RG, Blobel G, Kunkel HG (1982) Protein antigens of the RNA-protein complexes detected by anti-Sm and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders. J Exp Med 156:1475–1485Google Scholar
  6. 6.
    Sharp GC, Irvin WS, May CM, Holman HR, McDuffie FC, Hess EV, Schmid FR (1976) Association of antibodies to ribonucleoprotein and Sm antigens with mixed connective-tissue disease, systemic lupus erythematosus and other rheumatic diseases. N Engl J Med 295:1149–1154Google Scholar
  7. 7.
    Koffler D, Agnello V, Thoburn R, Kunkel HG (1971) Systemic lupus erythematosus: prototype of immune complex nephritis in man. J Exp Med (Suppl) 134:169S-179SGoogle Scholar
  8. 8.
    Nydegger UE, Lambert PH, Gerber H, Mescher PA (1974) Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen: quantitation by binding to radiolabeled Clq. J Clin Invest 54:297–309Google Scholar
  9. 9.
    Theofilopoulos AN, Dixon FJ (1979) The biology and detection of immune complexes. Adv Immunol 28:89–220Google Scholar
  10. 10.
    Valentijn RM, van Overhagen H, Hazevoet HM, Hermans J, Cats A, Daha MR, van Es LA (1985) The value of complement and immune complex determinations in monitoring disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 28:904–913Google Scholar
  11. 11.
    Kasep D, Agnello V, Kunkel HG (1977) In: Proceedings of the XII International Congress of Rheumatology, San Francisco Excerpta Medica, Amsterdam (abstr) p 69Google Scholar
  12. 12.
    Parker MD, Marion T (1977) Circulating complement-fixing immune complexes in mixed connctive tissue disease. Arthritis Rheum 20:130 (abstr)Google Scholar
  13. 13.
    Halla JT, Volanakis JE, Schrohenloher RE (1979) Circulating immune complexes in mixed connective tissue disease. Arthritis Rheum 22:484–489Google Scholar
  14. 14.
    Cunningham PH, Andrews RS, Davis JS IV (1980) Immune complexes in progressive systemic sclerosis and mixed connective tissue disease. J Rheumatol 7:301–308Google Scholar
  15. 15.
    Koffler D, Agnello V, Kunkel HG (1974) Polynucleotide immune complexes in serum and glomeruli of patients with systemic lupus erythematosus. Am J Pathol 74:109–122Google Scholar
  16. 16.
    Kurata N, Hara I, Kinashi M, Akita H, Ofuji T (1978) The correlation of antibodies to nuclear ribonucleoprotein (RNP) and nuclear acidic protein (Sm) with nephritis in patients with systemic lupus erythematosus (SLE). Contrib Nephrol 9:17–24Google Scholar
  17. 17.
    Maury CPJ, Teppo AM (1984) Demonstration of tissue 90 kD glycoprotein as antigen in circulating IgG immune complexes in dermatitis herpetiformis and coeliac disease. Lancet II:892–894Google Scholar
  18. 18.
    Triolo G, Giardina A, Bompiani GD (1984) IgA- and insulincontaining (C3-fixing) circulating immune complexes in diabetes mellitus. Clin Immunol Immunopathol 30:169–177Google Scholar
  19. 19.
    Hall RP, Lawley TJ (1985) Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis. J Immunol 135:1760–1765Google Scholar
  20. 20.
    Negoro N, Kanayama Y, Takeda T, Koda S, Inoue T. A solid-phase radioimmunoassay for the detection of nRNP immune complexes. J Immunol Methods 91:83–89Google Scholar
  21. 21.
    Tan EM, Cohen AS, Fries JF, Masi AT, Mcshane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ (1982b) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277Google Scholar
  22. 22.
    Morimoto C, Sano H, Abe T, Homma M, Steinberg AD (1982) Correlation between clinical activity of systemic lupus erythematosus and the amount of DNA in DNA/anti-DNA antibody immune complexes. J Immunol 129:1960–1965Google Scholar
  23. 23.
    Hill GS, Hinglais N, Tron F, Bach JF (1978) Systemic lupus erythematosus: morphologic correlations with immunologic and clinical data at the time of biopsy. Am J Med 64:61–79Google Scholar
  24. 24.
    Churg J, Sobin LH (1982) Renal disease: classification and atlas of glomerular disease. Igaku-shoin, Tokyo, pp 127–149Google Scholar
  25. 25.
    Decker JL, Steinberg AD, Reinertsen JL, Plotz PH, Balow JE, Klippel JH (1979) Systemic lupus erythematosus: evolving concepts. Ann Intern Med 91:587–604Google Scholar
  26. 26.
    Austin HA III, Muenz LR, Joyce KM, Antonovych TA, Kullick ME, Klippel JH, Decker JL, Balow JE (1983) Prognostic factors in lupus nephritis: contribution of renal histologic data. Am J Med 75:382–391Google Scholar
  27. 27.
    Balow JE, Austin HA III, Muenz LR, Joyce KM, Antonovych TA, Klippel JH, Steinberg AD, Plotz PH, Decker JL (1984) Effect of treatment on the evolution of renal abnormalities in lupus nephritis. N Engl J Med 311:491–495Google Scholar
  28. 28.
    Pereira AB, Theofilopoulos AN, Dixon FJ (1980) Detection and partial characterization of circulating immune complexes with solid-phase anti-C3. J Immunol 125:763–770Google Scholar
  29. 29.
    Wakabayashi K (1984) Analysis of the experimental data. Baifu-kan, Tokyo (in Japanese)Google Scholar
  30. 30.
    Miyagawa S, Sakamoto K (1981) Immune complexes in the sera of patients with anti-RNP antibodies. J Dermatol 8:21–26Google Scholar
  31. 31.
    Reichlin M, Mattioli M (1972) Correlation of precipitin reaction to an RNA protein antigen and low prevalence of nephritis in patients with systemic lupus erythematosus. N Engl J Med 286:908–911Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • N. Negoro
    • 1
  • Y. Kanayama
    • 1
  • T. Takeda
    • 1
  • K. Amatsu
    • 1
  • S. Koda
    • 1
  • Y. Inoue
    • 1
  • T. Kim
    • 1
  • M. Okamura
    • 1
  • T. Inoue
    • 1
  1. 1.First Department of Internal MedicineOsaka City University Medical SchoolOsakaJapan

Personalised recommendations