Summary
Transmission of mitochondrial factors was studied in zygote clones, random diploids, and zygote cell lineages. An asymmetrical distribution of both parental and recombinant classes was consistently seen. Genetic analysis indicated that a nuclear factor was controlling this pattern. Treatment of young zygotes with either cycloheximide or thiolutin for 90 minutes destroyed the pattern and randomized the distribution of parental and recombinant classes. Inhibition of mitochondrial protein synthesis with antibacterial antibiotics had no detectable effect on the pattern of distribution of mitochondrial markers.
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Communicated by W. Maas
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Waxman, M.F., Eaton, N. & Wilkie, D. Effect of antibiotics on the transmission of mitochondrial factors in Saccharomyces cerevisiae . Molec. Gen. Genet. 127, 277–284 (1973). https://doi.org/10.1007/BF00267098
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DOI: https://doi.org/10.1007/BF00267098