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A correlation between sensitization to gamma-rays by purine starvation and the rec genes in Escherichia coli K-12

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Summary

After purine staration the recombination proficient (Rec+) strains of E. coli K-12 tested were sensitized to inactivation by gamma-rays (Figs. 1–4). No such change was noted in the Rec− strains tested (Fig. 5). These results suggest that purine starvation may sensitize cells to ionizing radiation by inhibiting repair controlled by the recA, recB and recC genes.

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Authors and Affiliations

  1. Department of Radiation Biophysics, University of Kansas, Lawrence, Kansas, USA

    Jeremy E. Baptist, Frank M. Starkey, Benjamin S. Friesen & Dominic A. Scudiero

Authors
  1. Jeremy E. Baptist
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  2. Frank M. Starkey
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  3. Benjamin S. Friesen
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  4. Dominic A. Scudiero
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Cummunicated by E. M. Witkin

This paper was reported in part at the Fourteenth Annual meeting of the Biophysical Society in Baltimore, Md., 25–27 February 1970.

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Baptist, J.E., Starkey, F.M., Friesen, B.S. et al. A correlation between sensitization to gamma-rays by purine starvation and the rec genes in Escherichia coli K-12. Molec. Gen. Genet. 112, 36–42 (1971). https://doi.org/10.1007/BF00266930

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  • DOI: https://doi.org/10.1007/BF00266930

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