Summary
Subtotal synovectomy was performed on the right knee joints of 20 immature and 20 mature rabbits, and articular cartilage from the femoral and tibial condyles and the patellae was examined at 1, 3, 5 and 12 weeks after operation. Specimens from the unoperated left knees provided the controls.
Each specimen was examined macroscopically and with histological (H-E stain) and histochemical (safranin-O stain) techniques for abnormalities in structure, cell population, stain intensity and distribution.
The femoral articular cartilage was most affected by synovectomy. The tibial articular cartilage was only moderately affected and the patellar articular cartilage was even less affected. The histochemical changes were transient and reversble, being more severe and prolonged in the mature animals. No changes in either group were noted on gross inspection or in the H-E stained sections.
Résumé
Les auteurs ont réalisé une synovectomie subtotale du genou droit chez 20 lapins adultes et 20 jeunes. Le cartilage articulaire tibial et fémoral a été examiné à 1, 3, 5 et 12 semaines après l'opération. Des pièces provenant du genou opposé ont servi de contrôle.
Chaque prélèvement a été examiné macroscopiquement et à l'aide de techniques histologiques (par coloration à l'hématoxyline-éosine) et histochimiques (par coloration à la safranine-O) pour rechercher les anomalies de structure, la population cellulaire, l'intensité de la coloration et sa distribution.
Le cartilage articulaire fémoral est le plus modifié par la synovectomie. Le cartilage tibial n'est que modérément modifié et celui de la rotule l'est moins encore. Les modifications histochimiques sont transitoires et réversibles, mais plus importantes et plus durables chez les animaux adultes. Dans les deux groupes il n'a pas été noté de modifications à l'examen macroscopique ni sur les coupes colorées à l'hématoxyline-éosine.
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Moon, MS., Kim, JY. & Ok, IY. The effect of synovectomy on the articular cartilage of the knee joint in rabbits. International Orthopaedics 8, 247–253 (1985). https://doi.org/10.1007/BF00266868
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DOI: https://doi.org/10.1007/BF00266868