Summary
Details of four children with congenital skeletal abnormalities are reported. In one, typical of the Larsen Syndrome, an autosomal dominant pattern of inheritance is demonstrated. The three others show marked skeletal abnormalities similar to those seen in the Larsen Syndrome but without the usual characteristic facial features.
Résumé
Observations détaillées de quatre enfants porteurs d'anomalies squelettiques congénitales. Chez l'un d'entre eux, présentant un syndrome de Larsen typique, on a pu faire la preuve d'une transmission héréditaire autosomique dominante. Les trois autres étaient atteints d'anomalies squelettiques semblables à celles du syndrome de Larsen, mais sans les habituelles modifications caractéristiques du faciès.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Larsen, L. J., Schottstaedt, E. R., Bost, F. C.: Multiple congenital dislocations associated with characteristic facial abnormalities. J. Pediatr. 78, 291–298 (1971)
Latta, R. J., Graham, C. B., Aase, J., Scham, S. M., Smith, D. W.: A skeletal dysplasia with multiple joint dislocations and unusual facies. J. Pediatr. 78, 291–298 (1971)
Steel, H. H., Kohl, E. J.: Multiple congenital dislocations associated with other skeletal abnormalities (Larsen's syndrome) in three siblings. J. Bone Joint Surg. [Am.] 54, 75–82 (1972)
Micheli, L. J., Hall, E. J., Watts, H. G.: Spinal instability in Larsen's syndrome. J. Bone Joint Surg. [Am.] 48, 562–565 (1976)
Curtis, B. H., Fisher, R. L.: Heritable congenital tibio-femoral subluxation. Clinical features and surgical treatment. J. Bone Joint Surg. [Am.] 52, 1104–1114 (1970)
Haberman, E. T., Sterling, A., Dennis, R. I.: Larsen's syndrome: A heritable disorder. J. Bone Joint Surg. [Am.] 58, 558–561 (1976)
McKusick, V. A.: Heritable disorders of connective tissue. Ed. 4 St. Louis, C. V. Mosby 1972
McKusick, V. A.: Mendelian inheritance in man. John Hopkins University Press, Baltimore 1978
Harris, R., Cullen, C. H.: Autosomal dominant inheritance in Larsen's syndrome. Clin. Genet. 2, 87–90 (1971)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Samuel, A.W., Davies, D.R.A. The Larsen Syndrome with multiple congenital dislocations and a normal facies. International Orthopaedics 5, 229–232 (1981). https://doi.org/10.1007/BF00266688
Issue Date:
DOI: https://doi.org/10.1007/BF00266688