Summary
We have compared the biological behaviour of eight types of segmental tibial grafts in dogs under different immunological conditions: autografts, allografts, allografts with short-term immunosuppression (4 weeks), and allografts with longterm suppression (20 weeks). Some grafts were revascularised by microsurgical anastomosis, others were not. The long-term immunosuppressed allografts are most similar to autografts in terms of perfusion pattern and graft-host interface healing. The difference between long-term immunosuppressed allografts and allografts which were not immunosuppressed was highly significant (P<0.01). The viability of long-term immunosuppressed allografts, as measured by fluorochrome-labelled osteons, did not reach the level of the autografts, but still differed significantly from the allografts which were not immunosuppressed. Immunosuppression, therefore, improves the survival and the quality of the graft, more so for long-term immunosuppressed grafts, and also in revascularised grafts.
Résumé
Nous avons comparé, chez le chien, le comportement biologique de huit types de greffes segmentaires de tibia dans diverses conditions immunologiques : autogreffes, allogreffes, allogreffes avec courte immunosuppression (4 semaines), et allogreffes avec longue immunosuppression (20 semaines). Certaines greffes étaient revascularisées par anastomose micro-chirurgicale, d'autres ne l'étaient pas. Les allogreffes avec longue immunosuppression se sont révélées les plus semblables aux autogreffes sur le plan de la vascularisation et de l'évolution de l'interface hôte-greffon. La différence entre les allogreffes simples et celles avec longue immuno-suppression est hautement significative (P<0,01). La viabilité des allogreffes avec longue im muno-suppression, mesurée par les ostéons marqués au fluorochrome, n'a pas atteint le niveau des autogreffes, mais elle diffère significativement des allogreffes sans immunosuppression. En conclusion, l'immuno-suppression améliore la survie et la qualité des greffes, d'autant plus qu'elle est prolongée, de même que la revascularisation.
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SIROT-SICOT, Award, Munich, 1987
Supported by the Swiss National Foundation for Scientific Research, Grant 3-926-82; by an AO Research Grant and by Sandoz AG, Switzerland
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Aebi, M., Regazzoni, P. & Schwarzenbach, O. Segmental bone grafting. International Orthopaedics 13, 101–111 (1989). https://doi.org/10.1007/BF00266370
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DOI: https://doi.org/10.1007/BF00266370