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Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects

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Summary

The effects of single dose (20 mg) and short-term (20 mg/day for 8 days) oral treatment with omeprazole on the pharmacokinetics and effects of oral nifedipine (10 mg capsule) and on gastric pH have been investigated in a randomized, double-blind, placebo-controlled cross-over study in 10 non-smoking healthy male subjects.

The single dose of omeprazole had no significant effect on any pharmacokinetic parameter of nifedipine, nor on gastric pH, or blood pressure or heart rate.

Short-term omeprazole treatment increased the AUC of nifedipine by 26% (95% confidence interval 9–46%), but all other pharmacokinetic parameters of nifedipine, including elimination half-life, Cmax, tmax, and recovery of the main urinary metabolite, were not significantly changed. The median gastric pH during the absorption phase of nifedipine was increased by short-term omeprazole (pH 4.2) compared to placebo treatment (pH 1.4). Blood pressure and heart rate did not differ between treatments.

The interaction between nifedipine and omeprazole is not likely to be of major clinical relevance.

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Author notes

  1. P. van Brummelen

    Present address: Department of Clinical Pharmacokinetics/Dynamics, Hoffmann-La Roche Co., Basel, Switzerland

Authors and Affiliations

  1. Division of Pharmacology, Center for Bio-Pharmaceutical Sciences, University of Leiden, Leiden, The Netherlands

    P. A. Soons, G. van den Berg, M. Danhof & D. D. Breimer

  2. Department of Nephrology, Leiden University Hospital, Leiden, The Netherlands

    P. van Brummelen

  3. Department of Gastroenterology, Leiden University Hospital, Leiden, The Netherlands

    J. B. M. J. Jansen & C. B. H. W. Lamers

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  1. P. A. Soons
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Soons, P.A., van den Berg, G., Danhof, M. et al. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects. Eur J Clin Pharmacol 42, 319–324 (1992). https://doi.org/10.1007/BF00266355

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  • DOI: https://doi.org/10.1007/BF00266355

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