Summary
The authors describe the phenomena which lead to calcification of heart and skeletal muscle in dihydrotachysterol-treated rats. In the skeletal muscle the onset of mineral deposition is in the dilated vesicles of the sarcoplasmic reticulum. In heart muscle, on the contrary, calcification begins in the mitochondrial crystal. The results show that these differences are related to the physiopathological mechanism of muscle contraction.
Résumé
Les auteurs décrivent les phénomènes qui conduisent à la calcification du tissu musculaire, myocarde y compris, chez les rats traités par le déhydrotachystérol. Dans le muscle, le dépôt minéral commence au niveau des vacuoles dilatées du réticulum sarcoplasmique. Par contre, dans le myocarde, la calcification débute au niveau des mitochondries.
Ces résultats indiquent que les différences observées sont liées aux modalités particulières du mécanisme physiopathologique de la contraction musculaire.
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Perugia, L., Sadun, R. New trends in muscle calcification. International Orthopaedics 1, 165–170 (1977). https://doi.org/10.1007/BF00266333
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DOI: https://doi.org/10.1007/BF00266333