Abstract
Quantitative studies of 123I-iodide uptake using a gamma camera were undertaken in 23 infants with congenital hypothyroidism. Background oral radioactivity was reduced by ensuring that the infants drank fruit juice during the study. In 7 cases, there was no evidence of functioning thyroid tissue, in 13 cases, lingual tissue was present, and in 3 cases, there was uptake at the normal thyroid site. Dyshormonogenesis, as shown by a positive perchlorate discharge at 30–60 min after radioiodine administration, was present in 5 of the cases with demonstrable uptake. The estimated 20-min uptake of 123I-iodide was less than 2.6% of the dose in all cases except 1; in this case, the uptake was 10.4%, but this was completely discharged by perchlorate. There was good agreement between the quantitative radioiodine-uptake and-discharge results and the circulating thyroid-hormone levels. The estimated radiation dose to thyroid tissue using the technique was 9.2 mSv for an intravenous administration of 2MBq 123I-iodide.
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Formerly at the Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow G3 8SJ, Scotland
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Hilditch, T.E., Jackson, H.J. Quantitative 123I-iodide scintigraphy and radiation dosimetry in infants with congenital hypothyroidism. Eur J Nucl Med 11, 132–135 (1985). https://doi.org/10.1007/BF00265047
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DOI: https://doi.org/10.1007/BF00265047