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Archives of Toxicology

, Volume 59, Issue 1, pp 4–6 | Cite as

Studies on the genotoxicity of the anabolic drugs trenbolone and zeranol

  • M. Scheutwinkel
  • W. v. d. Hude
  • A. Basler
Original Investigations

Abstract

The androgen trenbolone, and the mycoestrogen zeranol, both anabolic drugs, were tested for their genotoxic potential. Test systems were the SOS-chromotest, the rec-assay and the V79 sister chromatid exchange test without and with metabolic activation using rat liver homogenates and primary rat hepatocytes.

It is still a matter of debate if trenbolone has carcinogenic properties, because of its cell transforming activity in vitro. Trenbolone, however, did not demonstrate any genotoxic effect in the assays performed. The results obtained for zeranol were also negative in the SOS-chromotest and V79 sister chromatid exchange test but positive in the rec-assay.

Key words

Genotoxicity Zeranol Trenbolone Anabolic drugs 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Scheutwinkel
    • 1
  • W. v. d. Hude
    • 1
  • A. Basler
    • 1
  1. 1.Max von Pettenkofer-Institut des BundesgesundheitsamtesBerlin 33

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