Abstract
This study was assigned to investigate the influence of calcium channel blockers (nimodipine and nifedipine) in comparison to other vasoactive drugs (nitroglycerin, dopamine) on pulmonary shunting (Qs/Qt). Fifty anesthetised patients scheduled for aortocoronary bypass operation were randomly allocated to 5 groups receiving one of the following drugs: (1) nimodipine 1.0 μg·kg-1·min-1; (2) nifedipine 0.7 μg·kg-1·min-1; (3) nitroglycerin (TNG) 0.5 μg ·kg-1·min-1; (4) dopamine; (5) μg·kg-1·min-1; (6) placebo (0.9% NaCl). Nimodipine as well as nifedipine led to a significant increase in cardiac output (+44%; +39%), pulmonary vascular resistance simultaneously decreased (-25%;-28%). PaO2 increased significantly (+16%; +13%), too, whereas Qs/Qt remained almost unchanged. In contrast, the increase in cardiac output induced by dopamine (+27%) was accompanied by a significant increase in shunting (+34%). TNG application did not alter Qs/Qt, but pulmonary artery pressure (PAP) decreased markedly (-19%).
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16 June 2023
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s00134-023-07124-6
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Boldt, J., Bormann, B.v., Kling, D. et al. RETRACTED ARTICLE: Influence of nimodipine and nifedipine on intrapulmonary shunting — a comparison to other vasoactive drugs. Intensive Care Med 13, 52–56 (1987). https://doi.org/10.1007/BF00263558
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DOI: https://doi.org/10.1007/BF00263558