Abstract
The methods we have tested are reliable for the labeling of granulocytes and monocytes as well as with colloidal substances and with soluble 99mTc-phytate. Supravital colorations and electronmicroscopic pictures do not show any damage of the cells caused by the labeling procedures. In the clinical application after the reinjection of the labeled granulocytes and monocytes, inflammations in the abdomen and in the bone could be proved and localized exactly. A final evaluation of the described methods and its differentiation from other diagnostic possibilities will only be possible after further investigations.
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References
Ducassou, D., Nouel, J.P., Brendel, A.: Le marquage des elements figurés du sang pur l'indium radioactif-Methodologie-Résultats-Indications. In: Radioaktive Isotope in Klinik und Forschung. 13. Band, 1. Teil 91–96, 1978
English, D., Andersen, B.R.: Labelling of phagocytes from human blood with 99mTc-sulphur colloid. J. Nucl. Med. 16, 5 (1975)
Goodwin, P.A., Doherty, P.W., Lipton, M.J.: Observations on the use of 111In labeled platelets in the detection of thrombosis in humans. World Federation of Nuclear Medicine and Biology. Second International Congress. Washington 1978
McAfee, J.G., Thakur, M.L.: Survey of radioactive agents for in vitro labelling of phagocytic leucocytes. I. Soluble agents. J. Nucl. Med. 17, 480 (1976)
McAfee, J.G., Thakur, M.L.: Survey of radioactive agents for in vitro labelling of phagocytic leucocytes. II. Particles. J. Nucl. Med. 17, 488 (1976)
Rabinowitz, Y.: Separation of lymphocytes, polymorphonuclear leucocytes and monocytes on glass columns, including tissue culture observations. Blood 23, 811 (1964)
Segal, A.W., Arnot, R.N., Thakur, M.L., Lavender, J.P.: Indium-111 labelled leucocytes for localisatzion of abscesses. Lancet, Nov. 13, 1976, 1056
Subramanian, G., McAfee, J.G., Mehter, A.: 99mTc-Stannous Phytate: A new in vivo colloid for imaging of the reticuloendothelial system. J. Nucl. Med. 14, 459 (1973)
Uchida, T., Kariyone, S.: Organ distribution of the 99mTc-labelled white cells. Nippon Ketsueki Gakki Zasshi 36, 78 (1973)
Uchida, T., Kariyone, S.: The use of In-m oxine labelled platelets for localisation of vascular thrombi in humans. J. Nucl. Med. 18, 628 (1978)
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Schroth, H.J., Müller, K.P., Berberich, R. et al. The application of radioactive labeled leucocytes for the proof of inflammations. Eur J Nucl Med 4, 359–363 (1979). https://doi.org/10.1007/BF00263304
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DOI: https://doi.org/10.1007/BF00263304