Abstract
A compound was synthetized, which by X-Ray diffraction studies proved to be hexahydrated sodium tripolyphosphate. By means of in vitro procedures, it was demonstrated that this compound was able to complex trivalent cations, and that 113mIn could be completely incorporated to it. In vivo studies in rats, and scans performed with this new radiopharmaceutical in humans showed its highly selective accumulation in metastasic bone tumors.
Similar content being viewed by others
References
Abrams, H.L., Spiro, R., Goldstein, N.: Metastasis in carcinoma: analysis of 1000 autopsied cases. Cancer 3, 74 (1950)
Adatepe, M.H., Elch, M., Archer, E., Sturder, R., Potchen, E.J.: The laboratory preparation of indium-labeled compounds. J. Nucl. Med. 9, 426 (1968)
Audrieth, L.F.: Inorganic Syntheses. 1st Ed., Vol. III, p. 87. New York: McGraw-Hill Book Co. Inc. 1950
Buraggi, G., Laurini, R., Ringhini, R., Rodari, A., Scaiano, D.: L'uso di emazie marcate con 99mTc e 113mIn per studi della milza. Rad. Med. 58, 655 (1972)
Castronovo, F.P., Wagner, H.N.: Factors affecting the toxicity of the element indium. Br. J. Exp. Path. 52, 543 (1971)
Castronovo, F.P., Callahan, R.J., Potsaid, M.S., Pendergrass, H.P., Neel, H.S.: A new 99mTc skeletal imaging radiopharmaceutical: 1-hydroxy-ethylidene-1,1-disodium phosphonate 99mTc complex (99mTc-HEDSPA). In Radiopharmaceuticals and labelled compounds. Proc. Symp. Copenhagen, 26–30 march 1973, Vol. I. p. 79. Vienna: IAEA 1973
Charkes, N.D.: Detection of metastasic cancer to bone by scintigraphy with Sr-87m. Am. J. Roentgenol. 91, 1121 (1964)
Cohen, Y., Perez, R., Henry, R., Bardy, A., Panneciere, C.: Utilisation du pyrophosphate de sodium marqué par le technétium 99m dans la scintigraphie du squelette. Compt. Rend. Acad. Sci. Paris 275, Série D, 1719 (1972)
Fleming, W.H., McIlraith, J.D., King, E.R.: Photoscanning of bone lesions utilizing strontium-85m. Radiology 77, 635 (1961)
Fong, S., Gonzalez, S., Cardenas, R., Oliva, J., Valladares, T., Fraga, A.: Empleo del In113m en scintigrafia humana. Rev. Cub. Med. 12, 29 (1973)
Fong, S.: Uso del Indio 113m en la preparación de radiofármacos para la gammagraf ia. M. Sc. Thesis. Academia de Ciencias de Cuba (1976)
Geschickter, C., Copeland, M.: Tumors of bone. Philadelphia, Lippincott 1949
Green, A.M.: Technetium-99m methylene diphosphonates. Results of clinical trials of a new skeleton imaging agent. VIth Congress ALASBIMN, Quito, Ecuador. Nov. 30-Dec. 4 (1976)
Jones, A.G., Davis, M.A.: Multidentate phosphonates as skeletal and myocardial infarct imaging agents (abstr.). J. Nucl. Med. 16, 540 (1975)
Jones, A.G., Davis, M.A., Dewanjee, M.K.: 113mIn-labeled bone scanning agents. Radiology 117, 727 (1975)
Moeller, T.: Contributions to the chemistry of Indium. III. An electrometric study of the precipitation of hydrous indium hydroxide. J. Am. Chem. Soc. 63, 2625 (1941)
Potchen, E.J., Adatepe, M., Welch, M.J., Archer, E., Studer, R.: In-113m for visualizing body organs. A broad spectrum scanning agent. J. Am. Med. Ass 205, 208 (1968)
Rhodes, B.A.: Radioactive albumin microspheres for studies of the pulmonary circulation. Radiology 9, 1453 (1969)
Simpson, W.J.K., Rotenberg, A.D., Baker, R.G.: Whole body scanning in medicine. II. Clinical aspects. Can. Med. Ass. J. 87, 371 (1962)
Subramanian, G., McAfee, J.G.: A new complex to Tc-99m for skeletal imaging. Radiology 99, 192 (1971)
Subramanian, G., Blair, R.J., Kallfelz, E.A.: 22mTc-MDP (methylene diphosphonate): A superior agent for skeletal imaging (abstr.). J. Nucl. Med. 14, 640 (1973)
Subramanian, G., McAfee, J.G., Rosenstreich, M., Coco, M.: Indium-labeled polifunctional phosphonates as bone-imaging agents. J. Nucl. Med. 16, 1080 (1975)
Wagner, H.N. Jr.: Present and future applications of radiopharmaceuticals from generator-produced radioisotopes. In: Radiopharmaceuticals from generator-produced radionuclides. Proc. Pannel, Vienna 1970. p. 163. Vienna: IAEA 1971
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fong, S., Zayas, F., Oliva, J. et al. 113mIn-tripolyphosphate: A new radiopharmaceutical for bone scanning. Eur J Nucl Med 4, 327–331 (1979). https://doi.org/10.1007/BF00263299
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00263299