Abstract
Tumor scintigraphic localization of neoplasms can be done in two ways: indirectly and directly.
The first method shows alternations of the normal structure of the organ, such as “cold lesions” in liver and thyroid. Abnormalities in function as increased permeability of the blood barrier results from abnormal deposition of the radionuclide in the brain scintigram of a patient with neoplasm. Increased focal areas of uptake of bone-seeking radionuclides are very characteristic of metastases.
The direct methods depend on preferential uptake of the radionuclide by the neoplastic tissue resulting from altered metabolism (e.g. Se-75). Other agents such as Gallium-67 have affinity for neoplasms.
Another approach is to use antineoplastic agents and radioactive antibodies which will localize in the tumor.
At this stage the most useful neoplasm seeking agents are Gallium-67 citrate and 111In-Bleomycin, even though infections can give false positives.
The possibility should be considered of enhancing the uptake of radionuclides by neoplastic cells using increased O2 concentration.
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Alvarez-Cervera, J., Arriaga-Sandoval, C., Maass-Escoto, R.: Estudios sobre un nuevo compuesto de estano y tecnecio para centelleografia renal (Presentation). 5th Latin-American Congress of Biol. and Nuclear Med., Bolivia, Nov. 1974
Anghileri, L.: Studies on relationship between 67 Ga-citrate accumulation and calcium metabolism in tumor cells. Nucl. Med. (Stuttg.) 12, 257 (1973)
Anderson, B.G., Beierwaltes, W.H., Harrison, T.S., Ansari, A.N., Busioivk, A.A., and Ice, R.D.: Labeled dopamine concentration in pheochromocitoma. J. Nucl. Med. 14, 781 (1973)
Bailey, T.B., Pinsky, S., Mitteneyer, B.T., Borski, A.A., Johnson, M.: New adjuvant in testis tumor staging with Ga 67 citrate. J. Neurol. 110, 307 (1973)
Basmadjian, G.P., Hetzel, X.R., Ice, R.D., Beierwaltes, W.H.: Synthesis of a new adrenal imaging agent: 6B I-131 iodomethyl-19 No cholest 5(10)-en 3. J. Nucl. Med. 16, 519 (1975)
Beierwaltes, W.H., Varma, V.M., Lieberman, L.M., Counsell, R.E., Morales, J.C.: Scintillation scanning of malignant melanomas with radioiodine quinoline derivatives. J. Lab. Clin. Med. 72, 485 (1968)
Bells, E.G.: Nuclear medicine and skeletal disease II. Hospital Practice 7, 57 (1973)
Bercy, A., Fiever, C., Moreaus, L.: The investigation of breast tumors by radiophosphorus scanning. Medicamundi 10, 66 (1965)
Berg, G.R.: 99mTc Diphosphonate concentration in primary breast carcinoma. Radiology 109, 393 (1973)
Bernstein, H., Zrafler, N., Ruben, M.J., Mansour, A.M. (Sr): The ocular deposition of chloroquine. Invest. Ophtamol 2, 384 (1963)
Blau, M.: Pancreas scanning with 75-Selenionmethionine. Medical radioisotope scanning, Vol. 2, p. 275. Vienna: International Atomic Energy Agency 1964
Briz-Kanafani, S., Alvarez-Cervera, J., Garcia-Sosa, I.: La Bleomicina y el cloruro aurico marcados con Au-198 en la gammagrafia cerebral. 9th Meeting of Mex. Soc. Nucl. Medicine. April, 1975
Brown, P.H., Swartzendruber, D.C., Carlton, J.E., Byrd, B.L., Hayes, R.L.: Isolation and characterization of gallium-binding granules from soft tissue tumors. Cancer Res. 33, 2063 (1973)
Brown, T.L., Broamer, S.R., Grove, R.B., Pinsky, S.M., Johnson, M.C.: Uptake of 67 Ga-citrate in sub-acute thyroiditis. J. Nucl. Med. 14, 403 (1973)
Burleson, R.L., Johnson, M.C., Head, H.: Scintigraphic demonstration of experimental abscesses with intravenous 67 Ga citrate and 67 Ga labeled blood leukocytes. Ann Surg. 178, 446 (1973)
Carmichael, P.L., Holst, G.C., Federman, J.L., Shields, J.A.: The present status of the 32-p test. Ophtalmology 4, 193 (1971)
Cavalieri, R.R., Scott, K.G., Sairenji, E.: Selenite (75-Se) as a tumor localizing agent in man. J. Nucl. Med. 7, 197 (1966)
Cellerino, P.G., Filippi, P.G., Chiantaretto, A., Borasio, P.: Operative and pathologic survey of 50 cases of peripheral lung tumors scanned with Gallium 67. Chest 64, 700 (1973)
Chaudhuri, T.K., Christie, J.H.: Tumor uptake of 99m-Tc polyphosphate. Its similarity with 87m-Sr citrate and dissimilarity with 67-Ga citrate. J. Nucl. Med. 15, 458 (1974)
Chauncey, D., Halpern, S.E., Alazraki, N.: Preparation and evaluation of 131-I tetracycline as a tumor scanning agent, Parts I and II (abstract). J. Nucl. Med. 16, 519 (1975)
Christensen, S.M., Dahlke, L.W., Griffin, J.T., Moutric, J.C., Jockner, K.L.: The effect of high-pressure O2 on acute radiation mortality in mice. Rad. Res. 37, 283 (1969)
Croll, M.N.: New techniques in tumor localization and radioimmunoassay. New York, London, Sydney, Toronto: J.W. Ley & Sons 1974
Deland, F.H., Sauerbrunn, B.J., Boyd, C., Wilkinson, R.H., Jr., Friedman, B.I., Mocnuddin, M., Preston, D.F., McKniseley, R.M.: 67 Ga citrate imaging in untreated primary lung cancer. Preliminary report of cooperative group. J. Nucl. Med. 15, 408 (1974)
Delisles, M.J., Valeyre, J.: Scintigraphie au bicholure de mercure. Ann. Med. (Reims) 6, 207 (1969)
De Nardo, G.L., DeNardo, S.J., Meyers, J., Krohn, K.: Tumor localization in animals and patients using radioiodinated bleomycin, J. Nucl. Med. 16, 525 (1975)
Dudley, H.C., Imirie, G.W., Jr., Istock, J.T.: Deposition of radio Gallium (Ga 67) in proliferating tissues. Radiology 55, 571 (1960)
Duran-Reynals, F.: Studies on the localization of dyes and foreign proteins in normal and malignant tumors. Am. J. Cancer 23, 98 (1939)
Dusault, L.A.: Effect of O2 in response to spontaneous tumors in mice to radiotherapy. Br. J. Radol. 36, 749 (1963)
Eckelman, W.C., Rzestortarski, B., Siegel, H., Kubota, H., Chellah, M., Reba, R.C.: The chemical and biological properties of isolated radiolabeled bleomycin components. J. Nuc. Med. 6, 526 (1975)
Edwards, C.L., Hayes, R.I.: Tumor scanning with 67 Ga citrate. J. Nucl. Med. 10, 103–105 (1969)
Edwards, C.L., Hayes, R.L.: Scanning malignant neoplasms with Gallium 67. JAMA 212, 1182 (1970)
Emmerson, D.A., O'Mara, R.E., Lilien, D.L.: Radiopharmaceutical works in progress (Session DD). 20th Annual Meeting of the Society of Nuclear Medicine, Miami Beach, Florida, June, 1973
Emmerson, D.A., O'Mara, R.E., Lilien, D.L.: 111 Indium-bleomycin as a tumor imaging agent. J. Nucl. Med. 14, 625 (1973)
Frankel, R.S., Jones, A.E., Cohen, J.A., Johnson, K.W., Johnston, G.S., Pomeroy, T.C.: Clinical correlations of 67 Ga and skeletal whole radionuclide studies with radiography in Ewing's sarcoma. Radiology 110, 597 (1974)
Freour, P., Blanquet, P., Branadon, M., Chomg, P., Chidler, M.: Peut-on diagnostiquer et localiser unotumeur maligne pulmonaire avec l'aide des radio-isotopes? Resultat d'une expérience avec le 197 Hg. Resp. Journées du 11 mai 1969
Fröhlich, J., Inoue, Y., Magnus, H.E.: Significance of 67 Ga citrate application for diagnosis of thoracic tumors. Fortschr. Geb. Roentgenstr. Nucl. Med. 119, 587 (1973)
Ganatra, R.D., Ramanathan, P., Patel, M.C., Memta, M.N., Shahani, S.N., Sharma, S.M., Mani, R.S., Norunha, O.P.D., Blau, M.: Radioiodinated synkol on a tumor-localizing agent. Medical radioisotope scintigraphy, Vol. 2, p. 25. Vienna: International Atomic Energy Agency 1969
Gardel, J., Isaac, R., Raynaud, C., Kellershohn, C.: Detection scintigraphique des tumeurs malignes à l'aide du bichlorure de mercure radioactif. Nos premiers résultats dans la domaine O.R.L. Ann. Oto. Laryng. (Paris) 54, 633 (1967)
Gelrud, L.C., Arseneau, S.C.: Kinetics of Gallium 67 incorporation into inflammatory lesions. Experimental and clinical studies. J. Nucl. Med. 23, 489 (1974)
Gold, P., Freedman, S.O.: Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121, 439, 1965
Goldenberg, D.M., Preston, D.F., Primus, J.: Photoscan localization of GW-39 tumors in hamsters using radiolabeled anti-CEA IgC. Cancer Res. (1973)
Weinstein, M.B.: Development and utilization of tumor localizing radiopharmaceuticals (111-In and 67 Ga). New techniques in tumor localization. Groll Brady, L.W., Honda, T. and Wallner, R.J. (Eds.), pp. 121–159. New York: wiley and Sons 1973
Goodwin, D.A., Goode, R., Brown, L., Imbornone, C.J.: 111 Indium-labeled transferrin for the detection of tumors. Radiology 100, 175 (1971)
Gotta, H., Chwojhik, A., Seeber, J.M., Pecorini, V.: Valoration de la centelleographia pulmonar con mercuriales. Medicine 32, 419 (1972)
Greenlaw, R.H., Weinstein, M.B., Brill, A.B.: 67 Ga-citrate imaging in untreated malignant lymphoma. J. Nucl. Med. 15, 404 (1974)
Grove, A.J., Kother, L.M.: Orbital scanning with multiple radionuclides. Arch. Ophtalmol. 89, 301 (1973)
Hagan, P., Halpern, S.E., Chauncey, D., Alazraki, N.: Comparison with Ga-67 and various Tc99m labeled agents, Part III. J. Nucl. Med. 16, 532 (1975)
Hagler, W.J., Jarrett, W.H., Schnauss, R.H., LaRose, J.H.: The diagnosis of malignant melanoma of the ciliary body or choroid. South. Med. J. 65, 1 (1972)
Hayes, R.L., Edwards, C.L.: New Applications for tumor-localizing radiopharmaceuticals, Medical radioisotope scintigraphy, Vol. 2, 1974
Heindel, N.D., Burns, D.H., Risch, V., Honda, T., Brody, L.W., Micalizzi, M.: I-131 streptozoctin analysis, tissue and tumor distribution studies. J. Nucl. Med. 16, 535 (1975)
Henkin, R.E., Polcyn, R.E., Quinn, J.L.: Scanning treated Hodgkin's disease with 67 Ga citrate. Radiology 110, 151 (1974)
Herbert, J.C., Eckelman, W.C., Reba, R.C., Scheis, P.C.: Bleomycin in the diagnosis of pancreatic cancer. J. Nucl. Med. 16, 533 (1975)
Herrera, N.E., Gonzales, R., Schwartz, R.D.: 75 Seleniomethionine as a diagnostic agent in malignant lymphoma. J. Nucl. Med. 6, 792 (1965)
Higashi, T., Hisada, T., Nakayama, Y.: Diagnosis of malignant tumor with 67 Ga-citrate. Radioisotopes 19, 318 (1970)
Hisada, K., Ando, A.: 169-Yb compound as a new cancer imaging substance. Igakunoayumi 82, 634–635
Hoffer, P.B., Turner, D.A., Gottschalk, A.: Whole-body radiogallium scanning for staging of Hodgkin's disease and other lymphomas. Natl. Cancer Inst. Monogr. 36, 277 (1973)
Hoffer, P.B., Lathrop, K., Bekerman, C., Fang, V.S., Refetoff, S.: Use of 131 I-CEA antibody as a tumor scanning agent. J. Nucl. Med. 15, 323 (1974)
Hoffer, P.D., Gottschalk, A.: New tumor scanning agents. Cancer 320 (1974)
Horn, N.L., Verma, R.C., Bennett, L.R.: Indium-111 Bleomycin scanning in the evaluation of malignant melanoma. J. Nucl. Med. 16, 537 (1975)
Hunter, W.W., Dekock, H.W.: 111-In for tumor localization. J. Nucl. Med. 10, 343 (1969)
Hunter, W.W., Riccobono, X.: Clinical evaluation of Indium 111 for localization of recognized neoplastic disease. J. Nucl. Med. 11, 328 (1970)
Ichikawa, T., Matsumoto, K., Umezawa, H.: Clinical study of a new antitumor antibiotic bleomycin. In Proceedings of the 5th International Congress of Chemotherapy. AIV-4135, June 1967, pp. 507. Vienna, Austria: International Atomic Energy Agency 1967
isaac, R., Raynaud, C., Kellershohn, C.: Detection scintigraphiques des tumeurs malignes à l'aide du 197 HgCl2. Nucl. Med. VII 2, 97 (1968)
Isaac, R., Van Quaetham, M., Raynaud, C., Blanchon, P.: Scintigraphies pulmonaires au 197 HgCl2 au cours d'atteintes néoplasiques et infectieuses du poumon. J. Fr. Med. Chir. Thor. 23, 771 (1969)
Isaac, R., Raynaud, C., Rymer, M.: Scintigraphies pulmonaires au 197 HgCl2. J. Fr. Med. Chir. Thor. 24, 225 (1970)
Isaac, R., Vanquatthem, M., Raynaud, C.: Scintigraphies pulmonaires au cours d'atteintes néoplasiques et infectieuses du images au 197 HgCl2. J. Fr. Med. Chir. Thor. 23, 771 (1969)
Isaac, R., Raynaud, C., Pymer, M., Monod, O.: Scintigraphies pulmonaires au 197 HgCl2. Résultats cliniques. J. Fr. Med. Ch. Thor. 3, 15 (1970)
Isaac, R.: Utilization du Bichlorure de Hg 197 pour le diagnostic en pathologie thoracique. Intérêt particulier dans la détection des tumeurs malignes. Thèse, Paris, 1970
Isitman, M., Komaki, S., Holms, R.A.: Benign uptake of 99mTc polyphosphatonate after radical mastectomy. Radiology 110, 158 (1974)
Jacobstein, J.G., Quinn, J.L.: Uptake of 206 Bi-citrate in carcinoma of the breast. Radiology 107, 677 (1973)
Jones, E., Frankel, R.S., Di Chiro, G., Johnston, G.S.: Brain scintigraphy and 67 Ga citrate. Radiology 112, 123 (1974)
Jovanovic, D., Bouckaert, A.: 75 Seleniomethionine as a tumor diagnostic agent. (Clinical and experimental study). Medical radioisotope scintigraphy, Vol. 2, p. 753, Brüssels, Belgium: International Atomic Energy, 1968
Kinoshita, F., Ushio, T., Maekawa, A., Ariwa, R., Kubo, A.: Scintiscanning of pulmonary diseases with 67 Ga citrate. J. Nucl. Med. 15, 227 (1974)
Kono, A., Pojima, M., Maeda, T.: A substance with affinity for malignant cancer 57 Co-bleomycin. Jap. J. Clin. Radiol. 18, 195 (1973)
Kumar, B., Alderson, P.O., Geisse, G.: The role of 67 Ga citrate imaging and diagnostic ultrasound in patients with suspected abdominal abscesses. J. Nucl. Med. 18, 534 (1977)
Lamy, P., Burg, C., Martin, J., Anthoine, D., Bertheau, J.M., Monneau, J.P., Vaillant, G., and Vaillant, D.: La scintigraphie pulmonaire au 197 HgCl2. Premières impressions à propos de 100 observations. Soc. Fr. Path. Resp., Séance du 17-11-68
Langhammer, H., Glaubett, G., Grebe, S.F., Hampe, J.F., Haubold, U., Hör, G., Kaul., Koeppe, P., Koppenhagen, J., Roedler, H.D., Van der Schoot, J.B.: 67 Ga for tumor scanning. J. Nucl. Med. 13, 25–30 (1972)
Lantieri, R.L., Honda, T., Brady, L.: Radiolabeled tumor antibody for tumor localization. J. Nucl. Med. 16, 544 (1975)
Larson, K.B., Cox, J.R.: Computer processing of dynamic images from a Gamma Scintillation camera. New York: Soc. Nucl. Med. 1974
Leh, F.K.V., Wolf, W.: 195Ptm Bleomycin in complexes for tumor imaging. J. Nucl. Med. 16, 544 (1975)
Littenberg, R.L., Taketa, R.M., Alazraki, N.P., Halpern, S.E., Ashburn, W.L.: Gallium 67 for localization of septic lesions. Ann. Inter. Med. 79-403 (1973)
Lomas, F., Dibos, P., Wagner, M.N. Jr.: Increased specificity of liver scanning. The use of 67-Gallium citrate. New Eng. J. Med. 286, 1329 (1972)
Lopez-Majano, V., Sion, A., Friedell, M.T.J., Chefec, G., Abraira, C.: Lymphosarcoma associated with subacute thyroiditis. Internat. Surg. 60, 172 (1975)
Lopez-Majano, V.: Indications for liver scintigraphy. Int. J. Surg. 59, 325 (1974)
Lopez-Majano, V.: Indications for scintigraphy in neoplastic disease. Int. J. Surg. 62, 408 (1977)
Low-Beer, B.V.A.: Surface measurements of radioactive phosphorous in breast tumors as a possible diagnostic method. Science 104, 399 (1946)
Maeda, T., Kono, A., Kojima, M.: Tumor scanning with 57 Co bleomycin. Radioisotopes 21, 436 (1972)
Mahaley, M.S. Jr.: Experiences with antibody production from human glioma tissue. Prog. Exp. Tumor Res. 17, 31 (1972)
Manfredi, O.L., Ramadan, F.: 67 Gallium scintigraphy, 4 years and 2,000 cases later. J. Nucl. Med. 16, 597 (1975)
Matsui, K., Iio, M., Chiba, K., Yamada, H., Abe, M., Hajime, M.: Diagnostic aid for the differential diagnosis of brain tumor C.V.D. by using Tc-99m pyrophosphate. J. Nucl. Med. 16, 549 (1975)
Mathews, C.M.E., Molinoro, G.: A study of the relative value of radioactive substances used for brain tumor localization and of the mechanisms of tumors, brain concentration and uptake in transplantable fibrosarcoma, brain and other organs in the rat. Brit. J. Exp. Pathol. 44, 260 (1963)
McCardle, R.J., Harper, P.V., Spar, I.L., Bale, W.F., Andros, G., Jiminez, F.: Studies with iodine 131 labeled antibody to human fibrinogen for diagnosis and therapy of tumors. J. Nucl. Med. 7, 837 (1966)
McNeil, B.J., Cassady, R.: Fluorine bone scintigraphy in children with osteosarcoma or Ewing's sarcoma. S. Afr. Med. J. 47, 2449 (1973)
Merrick, M.V., Gunasekera, S.W., Lavender, J.P.: A comparison of several chelates with 67 gallium in inflammatory and neoplastic lesions with a note on indium-labeled bleomycin. IAEA Symposium, Monte Carlo, October 23–28, 1972
Milder, M.S., Glick, J.H., Henderson, E.S., Johnston, G.S.: 67 Ga scintigraphy in acute leukemia. Cancer 32, 803 (1973)
Milder, M.S., Frankel, R.S., Bulkley, G.B., Ketcham, A.S., Johnston, G.S.: Gallium scintigraphy in malignant melanoma. Cancer 32, 1350 (1973)
Mishkin, F.S., Mealey, J. Jr.: Use and interpretation of brain scanning. Springfield, Ill.: Charles C. Thomas 1969
Mitchell, J.S., Marrian, D.H.: Radio sensitization of cells. Bichemistry of Quinones, R.A. Morton (ed.) Oxford: Academic Press 1965
Monod, O.: Les scintigraphies pulmonaires par injection d'iode et de mercure radioactifs. J. Fr. Med. Chir. Thor. 21, 717 (1967)
Monod, O.: La Scintigraphie pulmonaire en couleurs à l'iode et au mercure radioactifs. Poumon et cœur 23, 289 (1967)
Monod, O., Raynaud, C., Isaac, R., Rymer, M.: Scintigraphies pulmonaires avec Mercure radioactif. Présenté à Prague en Mai 1967. Soc. Chir. Thor. Française et Tcheocoslovaque, 1967
Monod, O., Raynaud, C., Isaac, R., Rymer, M.: Seintigraphies pulmonaires au mercure. Ann. Chir. Thor. Card. 7, 499 (1968)
Mori, F., Odori, T., Yamamoto, I., Sokamoto, T., Norita, R., Hamamoto, K., Torizuka, K., Hurutani, H.: Evaluation of 99m-Tc Bleomycin scintigraphy of various soft tissue involvement. J. Nucl. Med. 16, 551 (1975)
Mori, T., Hamamoto, K., Ishoi, Y.: Method for rapid preparation of 99m-Tc labeled compound by using stanous chloride. Jap. J. Nucl. Med. 9, 223 (1972)
Mori, T., Hamamoto, K., Onoyama, Y., Torizuka, K.: Tumor imaging after administration of 99m-Tc labeled bleomycin. J. Nucl. Med. 16, 414 (1975)
Mussa, C.: Results with Tc99m gluconate as a positive indication in the diagnosis of brain and lung cancers in children. J. Nucl. Med. 16, 522 (1975)
Nieto, L., Teran, E., Maisterrena, J.A.: Gammagrafia del nodula tiroideo hiperactive con polifosfato radioactivo. (Presentation) Mex. Soc. Nucl. Med. 1975
Nouel, J.P., Renault, H., Robert, J., Jeanne, C., Wicent, L.: La Bléomycine marquée au Co 57. Nouv. Presse Med. 1, 28 (1972)
Nouel, J.P., Robert, A., Witz, R., Mamo, G., Gest, B., Gaillard, D., Desgrez, M., Vergnes, P., Bru, C., Renault, H.: Radioactive isotopes in clinical medicine and research. Bad Gastein, Austria, Jan. 1972
O'Mara, R.E., Haber, K., Corrigan, J., Johnson, H., Lilien, D.: Indium-111 Bleomycin as a tumor scanning in pediatric oncology. J. Nucl. Med. 16, 554 (1975)
Parker, S., Lambrect, R.M., Wolf, A.P., Atkins, H.C.: Lead 203 tris as a melanoma localizing agent. J. Nucl. Med. 16, 556 (1975)
Parkey, R.W., Boute, F.J.: Experimental pertechnetate mammography. Radiology 111, 657 (1974)
Potchen, E.J., Watts, H.G., Awwad, H.K.: Parathyroid scintiscanning. Radiol. Clin. North Am. (A), 267 (1967)
Poulouse, K.P., Watkins, A.E., Reba, R.C., Eckelman, W.C., Goodyear, M.: Cobalt labeled bleomycin: A comparative clinical evaluation with Ga-67 Citrate in 500 patients with cancer. J. Nucl. Med. 16, 558 (1975)
Primus, F.J., Wang, R.H., Goldenberg, D.M., Hansen, H.J.: Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen. Cancer Res. 33, 2977 (1973)
Raynaud, C., Isaac, R., Rymer, M., Blanchon, P., Monod, O., Kellershohn, C.: Scintigraphies pulmonaires au 197 HgCl2. Fr. Med. Chir. Thor. 21, 735 (1967)
Raynaud, C., Comar, D., Dutheil, M., Blanchon, P., Monod, O., Parrot, R., Rymer, M.: Lung cancer, diagnosis with 67Cu (Preliminary results). J. Nucl. Med. 14, 947 (1973)
Rayudu, G.V.S., Kenoor, R., Ramachandran, P.C., Turner, D.A., Fordhan, E.W.: Tumor localization with adriamycin complexes of Gallium and mercury versus Ga (111) and Hg (11). J. Nucl. Med. 16, 560 (1975)
Rayudu, G.V.S., Kanoor, R., Ramachandran, P.C., Ali, A., Turner, D.A., Fordham, E.W.: Biological distribution of radiolabeled fibrinogen serum albumin and transferrin in tumor. J. Nucl. Med. 16, 560 (1975)
Renault, H., Henry, R., Rapin, J., Hegesippe, P.: Chelation de cations radioactives par un polypeptide. Colloque sur les Nouveautés en matière de radiopharmaceutiques et de composés marqués. Copenhague, March 26–30, 1973
Richman, S.D., Ingle, J.N., Levenson, S.M., Tormey, D.C., Jones, E., Johnston, G.S.: Gallium 67 in the detection of metastatic breast carcinoma. J. Nucl. Med. 16, 560 (1975)
Robbins, P.J., Silberstein, E.B., Fortman, D.L.: The preparation and distribution of 111 Indium bleomycin in mice as compared to 111 InCl3 for tumor scanning. J. Nucl. Med. 14, 637 (1973)
Rotman, M., Pogow, L., Roussis, K.: Radioisotope scanning of Kaposi's sarcoma: Modality for treated planning. Cancer, 33, 58 (1974)
Rubin, P., Poulter, C.A., Quick, R.S.: Changing perspective: Oxygen therapy and radiation therapy. Am. J. Roentgen. Radium Ther. Nucl. Med. 105, 665 (1969)
Rymer, M., Isaac, R., Raynaud, C., Kellershohn, C., Monod, O.: Scintigraphie pulmonaire au Mercure radioactif. J. Fr. Med. Chir. Thor. 21, 129 (1967)
Rymer, M.: Diagnostic des tumeurs malignes pulmonaires par la scintigraphie au mercure radio-actif. Thèse Paris, 1969
Sams, W.M., Jr., Epstein, V.W.: The affinity of melanin for choroquine. J. Invest. Ophtalmol 45, 482 (1965)
Seabold, J.E., Schteingart, D.E.: I-131 Iodo-colesterol imaging adrenal neoplasms. J. Nucl. Med. 16, 566 (1975)
Selverstone, B., Solomon, A.K., Sweet, W.H.: Localization of brain tumors by means of radioactive phosphorous. J. Am. Med. Assoc. 140, 227 (1946)
Siegel, M.E., Friedman, B.H., Wagner, H.N., Jr.: A new approach to breast cancer: Breast uptake of 99mTc Hedspa. JAMA 229, 1969 (1974)
Siemsen, J.K., Sargent, E.N., Grebe, S.F., Winsor, D.W., Wentz, D., Jacobson, G.: Pulmonary concentration of Ga 67 in Pneumoconiosis. Am. J. Roetgenol., Radium Nucl. Med. 120, 815 (1974)
Silberstein, E.B., Saenger, E.L., Tofe, A.J., Alexander, G.W., Park, H.: Imaging of bone metastasis with 99m-Tc Su-EHDP (Diphosphonate) 18F and skeletal radiography: A comparison of sensitivity. Radiology 107, 551 (1973)
Silberstein, E.B., Kornblut, A., Shumrick, D.A., Saenger, E.L.: Gallium 67 as diagnostic agent for detection of head and neck tumors and lymphoma. Radiology 110, 605 (1974)
Skromme-Kadlubik, G., Alvarez-Cervera, J., Cortes-Marmolejo, F.: Studies of suprarenal scintigram in humans using 131-DDD. J. Nucl. Med. 13, 282 (1972)
Sodee, D.B.: Radioisotope scanning of the pancreas with seleniomethionine 75-Se. Medical radioisotope scanning, Vol. 2, p. 289. Vienna: International Atomic Energy Agency 1964
Sodee, D.O.: Delineation of anatomic structures and detection of carcinoma utilizing low energy mercury labeled chlormerodrin. Radioaktive Isotope in Klinik und Forschung VI, 167 (1964)
Sotomayor, J.M., Flores, M.A.: El complejo tecnecio 99m Adriamicina, radiofarmaco con posible utilidad en localizacion de tumors. Presented at Mex. Soc. Nucl. Med. meeting, 1975
Spar, I.L., Bale, W.F., Goodland, R.L., DiChiro, G.: Preparation of purified I-131 labeled antisera to human fibrinogen Preliminary studies in human patients. Acta Int. Cancer 19, 197 (1963)
Spencer, R.P., Montana, G., Scanlon, G.F., Evans, O.R.: Uptake of seleniomethionine by mouse and human lymphomas, with observation on selinilte and selenate. J. Nucl. Med. 8, 197 (1967)
Sternberg, J., Imbach, A.: Metabolic studies with seleniated compounds. II Turnover studies with seleniomethionine-75 in rat. Int. J. Appl. Radiat. Isot. 18, 557 (1967)
Suzuki, T., and Matsumoto, Y.: Serum and Fetoprotein and Ga-67 citrate uptake in hepatoma. Am. J. Roentgenol, Radium Ther. Nucl. Med. 627, (1974)
Svanberg, L.: Clinical results of bleomycin treatment of bronchial carcinoma. Bleomycin Int. Symposium, Nov. 1972
Swartzendruber, D., Nelson, B., Hayes, R.L.: 67 Gallium localization in lysosomal-like granules of leukemic and nonleukemic murine tissues. J. Natl. Cancer Inst. 46, 941 (1971)
Thakur, M.L.: The preparation of 111-Indium bleomycin for tumor localization. Int. J. App. Radiat. 5, 24 (1973)
Thakur, M.L., Merrick, M.V., Gunnasekera, S.W., Lavender, J.P.: Proceedings of 1st International Symposium on Bleomycin, London, (1972). Welwyn, Herts, U.K.: Lundbeck Ltd 1973
Thomas, C.J., Krohner, S.S., Stareashi, J.P.: Detection of intraocular tumors with radioactive phosphorous. Arch. Ophtalmol. 47, 276 (1952)
Toole, J.F., Witcofski, R.: 75 Seleniomethionine scan for thymoma. JAMA 198, 1219 (1966)
Torizuka, K., Itoh, H., Ishii, Y., Suzuki, T., Sakamoto, T.: Radionuclide studies of bronchogenic carcinoma of the hilum. J. Nucl. Med. 16, 576 (1975)
Turner, D.A., Pinsky, S.M., Gottschalk, A., Hoffer, P.B., Uetmann, J.E., Harper, P.V.: The use of 67 Gallium in the staging of Hodgkin's disease. Radiology 104, 97 (1972)
Umezawa, H., Maeda, K., Takeuchi, T., Yoshiro, O.: New antibiotics, bleomycin, A and B. J. Antibiot. (Tokyo) Series A 200 (1966)
Van der Werff, J.T.: Radioactive bismuth-206: Experimental studies and clinical applications. Acta. Radiol. (Suppl.) Stockholm, 243, 52 (1965)
Verma, R.C., Bennett, L.R., Touya, J.J., Silberstein, E., Morton, A., Witt, B.: Radiopharmaceutical works in progress (Session DD). 20th Annual Meeting of the Society of Nuclear Medicine, Miami Beach, Florida, June, 1973
Verma, R.C., Bennett, L.R., Touya, J.J.: 111 Indium-bleomycin: A new radiopharmaceutical for tumor scintigraphy. J. Nucl. Med. 14, 641 (1973)
Verma, R.C., Silberstein, J.J., Greenfield, L.D., Bennett, L.R.: Correlation of Indium-111 Bleomycin breast scanning with other non-invasive techniques. J. Nucl. Med. 16, 544 (1975)
Wallner, R.J., Croel, M.N., Brady, L.W.: Ga 67 localization in acute cerebral infarction. J. Nucl. Med. 14, 308 (1973)
Waxman, A.D., Lee, G., Wolfstein, R., Siemsen, J.K.: Differential diagnosis of brain lesions by Gallium scanning. J. Nucl. Med. 14, 903 (1973)
Waxman, A.D., Kawada, T., Siemsen, J.K., Wolf, W.: Are all the gallium preparations equal? (abstract). J. Nucl. Med. 16, 580 (1975)
Waxman, A.D., Tanacescu, D., Siemsen, J.K., Wolfstein, R.S.: Technetium 99m glucoheptonate as a brain scanning agent, a critical comparison with pertechnetate. J. Nucl. Med. 16, 580 (1975)
Waxman, A.D., Siemsen, J.K.: Gallium scanning of cranial and extracranial infections. J. Nucl. Med. 16, 580 (1975)
Weinraub, J.M., Rosenberg, R., Irwin, G.A.L.: Technetium 90m polyphosphate in differential diagnosis of breast masses. J. Nucl. Med. 16, 581 (1975)
Wolf, R.J., Fischer, J.: Tumorszintigraphie mit radioaktiven Quecksilberverbindungen (197 HgCl, Neohydrin). 2 Tagung Ges, Nucklearmed. 22–24, 10 (1964)
Wolf, R., Fischer, J.: Szintigraphische Untersuchungen mit 197 HgCl2. 45. Dtsch. Röntgenkongress, Wiesbaden, 1964, p. 57. Stuttgart: G. Thieme 1965
Yano, Y.: Preparation and control of 68 Ga radiopharmaceuticals in Radiopharmaceuticals from generator-produced radionuclides. Vienna: IAEA 1970
Wright, E.A., Howard-Flanders, P.: The influence of oxygen on the radiosensitivity of mammalian tissues. Acta Radiologia. 48, 26 (1957)
Zaner, K.S., Damadran, R.: Phosphorous-31 as a nuclear probe for malignant tumors. Science 189, 729 (1975)
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Lopez-Majano, V., Alvarez-Cervera, J. Neoplasm localization with radionuclides. Eur J Nucl Med 4, 313–324 (1979). https://doi.org/10.1007/BF00263297
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DOI: https://doi.org/10.1007/BF00263297