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Immunohistochemical distribution of epithelial membrane antigen in bladder carcinomas as detected with a monoclonal antibody

Urological Research volume 17, pages 273–277 (1989)Cite this article

Summary

Expression of epithelial membrane antigen (EMA) was investigated immunohistochemically in 27 cases of bladder carcinoma using a monoclonal antibody. Normal urothelial epithelium showed EMA staining restricted to the upper layer of the surface epithelium. G-I transitional cell carcinomas demonstrated positive EMA staining which could be divided into the following 3 types; type 1, in which highly stained cells occurred in the upper layer of the neoplastic epithelium; type 2, in which the whole tumour focus was slightly stained; and type 3, in which cells strongly positive for EMA were scattered throughout the tumour focus. G-III (undifferentiated) transitional cell lesions exhibited irregular expression of EMA whereas squamous cell demonstrated specific intense EMA staining within keratinized tumour cells.

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Affiliations

  1. First Department of Pathology, Nagoya City University Medical School, Nagoya

    M. Asamoto & S. Fukushima

  2. Department of Oral Surgery, Asahi University School of Dentistry, Gifu, Japan

    H. Oosumi, Y. Tatemoto & M. Mori

Authors
  1. M. Asamoto
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  2. S. Fukushima
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  3. H. Oosumi
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  4. Y. Tatemoto
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  5. M. Mori
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Asamoto, M., Fukushima, S., Oosumi, H. et al. Immunohistochemical distribution of epithelial membrane antigen in bladder carcinomas as detected with a monoclonal antibody. Urol. Res. 17, 273–277 (1989). https://doi.org/10.1007/BF00262981

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  • DOI: https://doi.org/10.1007/BF00262981

Key words

  • Bladder carcinoma
  • Epithelial membrane antigen
  • Immunoperoxidase technique