Summary
Urine-Tissue Polypeptide Antigen (U-TPA) was measured in 81 patients with a previously diagnosed bladder carcinoma. U-TPA was elevated in 74% of the patients with invasive bladder cancer as compared to only 15% of the patients with superficial tumors. Only one patient without a tumor recurrence had an elevated U-TPA level (4%). The results were compared with cytological grading and flow-DNA measurements in a multivariate analysis with T-category as the result variable. U-TPA and grade showed each, independently, a significant relation (P≪0,001) to T-category whereas the result of the DNA measurements did not explain the variation in T-category when U-TPA and grade were already in the equation. For diagnostic purposes U-TPA seems to be of limited value but may serve as an indicator of tumor recurrence in bladder cancer patients.
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Carbin, B.E., Ekman, P., Eneroth, P. et al. Urine-TPA (Tissue Polypeptide Antigen), flowcytometry and cytology as markers for tumor invasiveness in urinary bladder carcinoma. Urol. Res. 17, 269–272 (1989). https://doi.org/10.1007/BF00262980
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DOI: https://doi.org/10.1007/BF00262980